| Autor: |
Siste K; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Pandelaki J; Department of Radiology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Miyata J; Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan., Oishi N; Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan., Tsurumi K; Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan., Fujiwara H; Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.; Decentralized Big Data Team, RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.; The General Research Division, Osaka University Research Center on Ethical, Legal, and Social Issues, Osaka 565-0871, Japan., Murai T; Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan., Nasrun MW; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Wiguna T; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Bardosono S; Department of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Sekartini R; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Sarasvita R; Faculty of Psychology, Soegijapranata University, Central Java 50234, Indonesia., Murtani BJ; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Sen LT; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia., Firdaus KK; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta 10430, Indonesia. |
| Abstrakt: |
Problematic internet use (PIU) is increasingly recognized as a mental health concern, particularly among adolescents. The resting-state functional connectivity (rsFC) of the triple-network model has been described inconsistently in PIU. Using resting-state fMRI (rsFMRI) and hypothesizing a lower rsFC between default mode (DMN) and central executive networks (CEN) but a higher rsFC within the salience network (SN), this study scrutinized the neural substrates of PIU adolescents. A total of 30 adolescents with PIU and 30 control subjects underwent rsFMRI. The severity of PIU was evaluated by the Internet Addiction Test. Additionally, personality traits as well as emotional and behavioral problems were evaluated by the Temperament and Character Inventory (TCI) and the Strength and Difficulties Questionnaire (SDQ), respectively. Focusing on the DMN, SN, and CEN, we compared rsFC values between PIU and the control. Subsequently, within the combined group of subjects, TCI and SDQ correlation and mediation effects were investigated. Higher rsFC values of the left lateral prefrontal cortex (LPFC(L)) with the left anterior insula (aIns(L)) were observed for PIU than for the control, while rsFCs of the LPFC(L) with the medial PFC (MPFC), LPFC(L), as well as with the right lateral parietal cortex (LP(R)) were lower for PIU. Among these significant group differences, the rsFC between the LPFC(L) and MPFC was mediated by emotional symptoms (standardized β = -0.12, 95% CI -0.29, -0.0052). The dysfunctional attention switching and incentive salience regulated by the SN were implicated as being a neural correlate of PIU, and this relationship would in part be explained by the emotional dysregulation associated with PIU in adolescents. |
