Workplace Culture and Biomarkers of Health Risk.

Autor: Shuck B; College of Education and Human Development, University of Louisville, Suite #346, Louisville, KY 40292, USA., Hart JL; Department of Communication, College of Arts and Sciences, University of Louisville, Louisville, KY 40292, USA.; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA., Walker KL; Department of Communication, College of Arts and Sciences, University of Louisville, Louisville, KY 40292, USA.; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA., Rai J; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA., Srivastava S; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA., Srivastava S; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA.; Division of Environmental Medicine, School of Medicine, Louisville, KY 40202, USA., Rai S; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA.; Division of Environmental Medicine, School of Medicine, Louisville, KY 40202, USA.; Brown Cancer Center, Biostatistics and Bioinformatics Facility, University of Louisville, Louisville, KY 40202, USA.; Biostatistics and Informatics Core, Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY 40202, USA.; Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40202, USA., Bhatnagar A; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA.; Division of Environmental Medicine, School of Medicine, Louisville, KY 40202, USA., Keith RJ; Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA.; Division of Environmental Medicine, School of Medicine, Louisville, KY 40202, USA.
Jazyk: angličtina
Zdroj: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Sep 21; Vol. 19 (19). Date of Electronic Publication: 2022 Sep 21.
DOI: 10.3390/ijerph191911920
Abstrakt: Workplace culture has been studied for impact on health risk; however, connections with robust biologic markers of health remain to be established. We examined associations between the work environment and urinary levels of catecholamines and their metabolites as biomarkers of sympathetic nervous system activity, indicative of stress. We recruited participants (n = 219; 2018-2019) from a cardiovascular risk cohort to investigate workplace culture, well-being, and stress. Participants completed seven questionnaires. Urine samples were used to measure catecholamines and their metabolites by LC/MS/MS. Pearson correlation and linear regression models were used after adjusting for demographics and creatinine. Participants reporting higher well-being had lower urinary levels of dopamine, serotonin, and 3-methoxytyramine. Participants reporting a more engaged and more positive workplace had lower levels of dopamine and 3-methoxytyramine. Reported workplace isolation was correlated with higher levels of dopamine and 3-methoxytyramine. Given correlations between catecholamines, we used 3-methoxytyramine for linear regression. In fully adjusted models, in environments with a more positive culture, levels of 3-methoxytyramine remained lower (β = -0.065 ± 0.025, p = 0.01) and indicated a positive association between workplace isolation and 3-methoxytyramine (β = 0.064 ± 0.030, p = 0.04). These findings are consistent with an important relationship between workplace environment and sympathetic nervous system activity.
Databáze: MEDLINE
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