[ 18 F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease.

Autor: Doot RK; Division of Nuclear Medicine Imaging and Therapy, Department of Radiology in the Perelman, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Young AJ; Division of Nuclear Medicine Imaging and Therapy, Department of Radiology in the Perelman, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Nasrallah IM; Division of Nuclear Medicine Imaging and Therapy, Department of Radiology in the Perelman, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wetherill RR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Siderowf A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Mach RH; Division of Nuclear Medicine Imaging and Therapy, Department of Radiology in the Perelman, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Dubroff JG; Division of Nuclear Medicine Imaging and Therapy, Department of Radiology in the Perelman, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jazyk: angličtina
Zdroj: Cells [Cells] 2022 Sep 30; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 30.
DOI: 10.3390/cells11193081
Abstrakt: Neuroinflammation is implicated as a key pathologic mechanism in many neurodegenerative diseases and is thought to be mediated in large part by microglia, native phagocytic immune cells of the CNS. Abnormal aggregation of the protein α-synuclein after phagocytosis by microglia is one possible neuropathophysiological mechanism driving Parkinson's disease (PD). We conducted a human pilot study to evaluate the feasibility of targeting the inducible isoform of nitric oxide synthase using the [ 18 F]NOS radiotracer to measure neuroinflammation in idiopathic PD. Ten adults consisting of 6 PD patients and 4 healthy controls (HC) underwent one hour of dynamic [ 18 F]NOS positron emission tomography (PET) brain imaging with arterial blood sampling. We observed increased [ 18 F]NOS whole brain distribution volume (V T ) in PD patients compared to age-matched healthy controls ( p < 0.008) via a 1-tissue compartment (TC) model. The rate constant K1 for transport from blood into tissue did not differ between groups ( p = 0.72). These findings suggest elevated oxidative stress, a surrogate marker of inflammation, is present in early-stage idiopathic PD and indicate that [ 18 F]NOS PET imaging is a promising, non-invasive method to measure neuroinflammation.
Databáze: MEDLINE
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