Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults.

Autor: Sible IJ; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Yew B; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Jang JY; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Alitin JPM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Li Y; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Gaubert A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Nguyen A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Dutt S; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA., Blanken AE; San Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, 94158, USA., Ho JK; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Marshall AJ; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Kapoor A; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA., Shenasa F; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA., Rodgers KE; Department of Pharmacology, Center for Innovation in Brain Science, The University of Arizona, Tucson, AZ, 85721, USA., Sturm VE; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Head E; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA., Martini A; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA., Nation DA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA. dnation@uci.edu.; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA. dnation@uci.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Oct 13; Vol. 12 (1), pp. 17197. Date of Electronic Publication: 2022 Oct 13.
DOI: 10.1038/s41598-022-20627-4
Abstrakt: Blood pressure variability is an emerging risk factor for Alzheimer's disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer's disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer's disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55-88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ 1-42 (standardized ß =  - 0.36 [95% CI - 0.61, - 0.12]; p = 0.005; adjusted R 2  = 0.28) and Aβ 1-42 : Aβ 1-40 ratio (ß =  - 0.49 [95% CI - 0.71, - 0.22]; p < 0.001; adjusted R 2  = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R 2  = 0.19) and Ptau 181 :Aβ 1-42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R 2  = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer's disease pathophysiology.
(© 2022. The Author(s).)
Databáze: MEDLINE
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