Assessing Coronary Artery and Aortic Calcification in Patients with Prostate Cancer Using 18 F-Sodium Fluoride PET/Computed Tomography.

Autor:	Raynor WY; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Department of Radiology, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB #404, New Brunswick, NJ 08901, USA., Borja AJ; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Zhang V; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Kothekar E; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Lau HC; Department of Medicine, Crozer-Chester Medical Center, 1 Medical Center Boulevard, Upland, PA 19013, USA., Ng SJ; Department of Medicine, Crozer-Chester Medical Center, 1 Medical Center Boulevard, Upland, PA 19013, USA., Seraj SM; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Rojulpote C; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Taghvaei R; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Jin KY; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Werner TJ; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark. Electronic address: https://twitter.com/pfhcrsyd.dk., Alavi A; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA., Revheim ME; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Problemveien 7, 0315 Oslo, Norway; Division of Radiology and Nuclear Medicine, Postbox 4950, Nydalen, Oslo 0424, Norway. Electronic address: mona.elisabeth.revheim@ous-hf.no.
Jazyk:	angličtina
Zdroj:	PET clinics [PET Clin] 2022 Oct; Vol. 17 (4), pp. 653-659.
DOI:	10.1016/j.cpet.2022.07.009
Abstrakt:	The aim of this study was to assess coronary artery and aortic calcification in healthy controls, angina pectoris patients, and prostate cancer patients using 18F-sodium fluoride PET/computed tomography (NaF-PET/CT). A retrospective analysis compared 33 prostate cancer patients with 33 healthy subjects and 33 patients with angina pectoris. Increased target-to-background ratio (TBR) of the coronary arteries, ascending aorta, aortic arch, and descending aorta was observed in cancer patients compared to healthy controls but not compared to angina pectoris patients. These results demonstrate the feasibility of assessing vascular microcalcification with NaF-PET/CT, with significant differences in uptake according to comorbidities. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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