Tranexamic acid effects in postoperative bleeding outcomes in laparoscopic sleeve gastrectomy: a controlled study.

Autor:	Brito RM; Ms. Hospital São Domingos - Center for Bariatric and Metabolic Surgery - Sao Luis (MA), Brazil., Oliveira CMB; PhD. Universidade Federal do Maranhão - Postgraduate Program in Adult Health - Sao Luis (MA), Brazil., Moura ECR; PhD. Universidade Federal do Maranhão - Postgraduate Program in Adult Health - Sao Luis (MA), Brazil., Campelo GP; Ms. Hospital São Domingos - Center for Bariatric and Metabolic Surgery - Sao Luis (MA), Brazil., Lima RC; Ms. Hospital São Domingos - Center for Bariatric and Metabolic Surgery - Sao Luis (MA), Brazil., Fe CSM; Graduate student. Universidade Federal do Maranhão - Department of Medicine - Sao Luis (MA), Brazil., Sousa TM; Graduate student. Universidade Federal do Maranhão - Department of Medicine - Sao Luis (MA), Brazil., Oliveira EJSG; PhD. Universidade Federal do Maranhão - Postgraduate Program in Adult Health - Sao Luis (MA), Brazil., Dibai Filho AV; PhD. Universidade Federal do Maranhão - Postgraduate Program in Adult Health - Sao Luis (MA), Brazil., Leal PDC; PhD. Universidade Federal do Maranhão - Postgraduate Program in Adult Health - Sao Luis (MA), Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2022 Oct 10; Vol. 37 (7), pp. e370702. Date of Electronic Publication: 2022 Oct 10 (Print Publication: 2022).
DOI:	10.1590/acb370702
Abstrakt:	Purpose: To demonstrate through a controlled study whether the use of tranexamic acid in bariatric surgeries is effective for bleeding control. Methods: Prospective, comparative, and double-blind study performed with patients from 18 to 65 years old submitted to bariatric surgery. The selected patients received venous tranexamic acid (TXA) during the induction of anesthesia or not (CG). The anesthesia and thromboprophylaxis protocols were similar among the groups. For statistical analysis, the χ2 and analysis of variance tests were performed at a significance level of p < 0.05, using the statistical program SPSS 21.0®. Results: Sixty-one patients were included in the study, 31 in the control group and 30 in the TXA group (GTXA). In the intraoperative period, the bleeding volume was greater in the CG than in the GTXA. In the postoperative period, the tranexamic acid group had a higher value hematocrit, absence of surgical reoperations due to bleeding complications, and shorter hospitalization time than the control group. Conclusions: The use of tranexamic acid was effective in reducing bleeding rates and of hospital stay length, in addition to demonstrating the clinical safety of its use, for not having been associated with any thromboembolic events.
Databáze:	MEDLINE
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