Case Report: Retinal Vasculitis in Two Adolescents After COVID-19 Vaccination.

Autor: Mohamed S; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Chan CK; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Tsang CW; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Szeto SK; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Fong AH; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Chan JC; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China., Wong CY; Hong Kong Eye Hospital, Kowloon, Hong Kong.; Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Shatin, China.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 Aug; Vol. 31 (6), pp. 1245-1249. Date of Electronic Publication: 2022 Oct 13.
DOI: 10.1080/09273948.2022.2129694
Abstrakt: Purpose: To report two cases of bilateral retinal vasculitis in adolescents following COVID-19 vaccination.
Study Design: Case report.
Results:  We report the first two cases of retinal vasculitis in adolescents following COVID-19 vaccinations. Both patients received recent second-dose COVID-19 vaccinations (7 weeks and 4 weeks respectively), and presented with bilateral retinal vasculitis and vitritis. Investigations did not reveal other causes of retinal vasculitis. Both patients' retinal vasculitis settled with a short course of oral prednisolone.
Conclusion: Although rare, the temporal association between vaccination, bilateral eye involvement, and the absence of alternative infective or inflammatory causes, makes this a plausible etiology. mRNA vaccinations may cause an autoimmune reaction via host antigenic mimicry, and systemic vasculitis has previously been described. We believe that a short interval between COVID-19 vaccination doses might be a risk factor for the development of retinal vasculitis in adolescents, and clinicians should be aware to elicit vaccination history.
Databáze: MEDLINE
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