The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years.

Autor:	De Carvalho M; Stowers Institute for Medical Research, Kansas City, United States.; Open University, Milton Keynes, United Kingdom., Jia GS; PTN Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing, China.; National Institute of Biological Sciences, Beijing, Beijing, China., Nidamangala Srinivasa A; Stowers Institute for Medical Research, Kansas City, United States.; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, United States., Billmyre RB; Stowers Institute for Medical Research, Kansas City, United States., Xu YH; National Institute of Biological Sciences, Beijing, Beijing, China., Lange JJ; Stowers Institute for Medical Research, Kansas City, United States., Sabbarini IM; Stowers Institute for Medical Research, Kansas City, United States., Du LL; National Institute of Biological Sciences, Beijing, Beijing, China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China., Zanders SE; Stowers Institute for Medical Research, Kansas City, United States.; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2022 Oct 13; Vol. 11. Date of Electronic Publication: 2022 Oct 13.
DOI:	10.7554/eLife.81149
Abstrakt:	Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver- heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans because a driver gene or gene family is often found in a single species or in a group of very closely related species. Additionally, drivers are generally considered doomed to extinction when they spread to fixation or when suppressors arise. In this study, we examine the evolutionary history of the wtf meiotic drivers first discovered in the fission yeast Schizosaccharomyces pombe . We identify homologous genes in three other fission yeast species, S. octosporus , S. osmophilus , and S. cryophilus , which are estimated to have diverged over 100 million years ago from the S. pombe lineage. Synteny evidence supports that wtf genes were present in the common ancestor of these four species. Moreover, the ancestral genes were likely drivers as wtf genes in S. octosporus cause meiotic drive. Our findings indicate that meiotic drive systems can be maintained for long evolutionary timespans. Competing Interests: MD, GJ, AN, RB, YX, JL, IS, LD, SZ No competing interests declared (© 2022, De Carvalho, Jia et al.)
Databáze:	MEDLINE
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