Antidepressant-Like Effect and Phenolic Profile of Brazilian Native and Exotic Species from Psidium Genus.

Autor: Cavichioli N; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil., Dalmagro AP; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil., Sasse OR; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil., Junges LH; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil., Rebelo AM; Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina, EPAGRI, CEP 88318-112, Itajaí, Santa Catarina, Brazil., Reinke CK; Serviço Nacional de Aprendizagem Industrial, SENAI, Instituto SENAI de Tecnologia Ambiental, CEP 89637-050, Blumenau, Santa Catarina, Brazil., Zeni ALB; Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil.; Programa de Pós-Graduação em Biodiversidade, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2022 Nov; Vol. 19 (11), pp. e202200242. Date of Electronic Publication: 2022 Nov 03.
DOI: 10.1002/cbdv.202200242
Abstrakt: Depression is one of the disorders involving mental health that most affects the population worldwide. Considering the available pharmacological therapies for the treatment of depression are ineffective in most patients, the search for new alternatives is crucial. In line with this, we investigated the phenolic profile, antidepressant-like, and antioxidant effects triggered by the administration of aqueous extracts from Psidium guajava L. (GUA), Psidium cattleianum Sw. (CAT), and Psidium guineense Sabine (GUI) leaves in mice. Our results show that quercetin is the major compound of GUA and GUI, and o-coumaric acid in CAT extracts. The acute and subchronic administrations of the three plant extracts exerted an antidepressant-like effect in mice exposed to the tail suspension test, without changes on locomotor performance evaluated by the open field test. Furthermore, the GUI and CAT decreased oxidative stress markers, mainly lipid peroxidation and nitrites in the hippocampus, prefrontal cortex, liver, and plasma. Notably, GUA and CAT increased non-protein thiols in all tissues. Therefore, the Psidium extracts demonstrated an antidepressant-like effect in mice, and the antioxidant capacity of the extracts seems to underlie the behavioral effect.
(© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
Externí odkaz: