Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects.

Autor:	Radovanović J; University of Belgrade School of Dental Medicine, Clinic for Paediatric and Preventive Dentistry, Belgrade, Serbia.; University of Belgrade, Vinča Institute of Nuclear Sciences, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia., Antonijević B; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Baralić K; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Ćurčić M; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Đukić-Ćosić D; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Bulat Z; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Javorac D; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Buha Đorđević A; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Kotur-Stevuljević J; University of Belgrade Faculty of Pharmacy, Department of Biochemistry, Belgrade, Serbia., Sudar-Milovanović E; University of Belgrade, Vinča Institute of Nuclear Sciences, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia., Antonijević Miljaković E; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Beloica M; University of Belgrade School of Dental Medicine, Clinic for Paediatric and Preventive Dentistry, Belgrade, Serbia., Mandinić Z; University of Belgrade School of Dental Medicine, Clinic for Paediatric and Preventive Dentistry, Belgrade, Serbia.
Jazyk:	angličtina
Zdroj:	Arhiv za higijenu rada i toksikologiju [Arh Hig Rada Toksikol] 2022 Sep 30; Vol. 73 (3), pp. 207-222. Date of Electronic Publication: 2022 Sep 30 (Print Publication: 2022).
DOI:	10.2478/aiht-2022-73-3650
Abstrakt:	This study aimed to investigate the effect of 150 mg/L sodium fluoride (NaF) on redox status parameters and essential metals [copper (Cu), iron (Fe), and zinc (Zn)] in the blood, liver, kidney, brain, and spleen of Wistar rats and to determine the protective potential of selenium (Se) against fluoride (F - ) toxicity. Male Wistar rats were randomly distributed in groups of five (n=5) receiving tap water (control) or water with NaF 150 mg/L, NaF 150 mg/L + Se 1.5 mg/L, and Se 1.5 mg/L solutions ad libitum for 28 days. Fluorides caused an imbalance in the redox and biometal (Cu, Fe, and Zn) status, leading to high superoxide anion (O 2 .- ) and malondialdehyde (MDA) levels in the blood and brain and a drop in superoxide dismutase (SOD1) activity in the liver and its increase in the brain and kidneys. Se given with NaF improved MDA, SOD1, and O 2 .- in the blood, brain, and kidneys, while alone it decreased SH group levels in the liver and kidney. Biometals both reduced and increased F- toxicity. Further research is needed before Se should be considered as a promising strategy for mitigating F - toxicity. (© 2022 Jelena Radovanović, Biljana Antonijević, Katarina Baralić, Marijana Ćurčić, Danijela Đukić-Ćosić, Zorica Bulat, Dragana Javorac, Aleksandra Buha Đorđević, Jelena Kotur-Stevuljević, Emina Sudar-Milovanović, Evica Antonijević Miljaković, Miloš Beloica, and Zoran Mandinić, published by Sciendo.)
Databáze:	MEDLINE
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