Cytoprotective effect of Fridericia chica (Bonpl.) L.G. Lohmann extract associated with geranylgeraniol enriched-fraction from Bixa orellana L. on epithelial cells treated with bisphosphonate.

Autor:	Machado Júnior RJ; School of Medical Sciences, University of Campinas, Campinas, Brazil., Camilli JC; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Basting RT; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Zago PMW; São Leopoldo Mandic Medical School, Araras, Brazil., Sousa IMO; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Buglio KE; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Ruiz ALTG; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Carvalho PRN; CCQA/ITAL, Campinas, Brazil., Carvalho JE; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil., Saad STO; Hematology and Hemotherapy Center (HEMOCENTRO), State University of Campinas (UNICAMP), Campinas, Brazil., Foglio MA; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2023 Aug-Sep; Vol. 37 (16), pp. 2776-2781. Date of Electronic Publication: 2022 Oct 13.
DOI:	10.1080/14786419.2022.2131782
Abstrakt:	Bisphosphonates are drugs used to treat bone disorders. The chronic use of bisphosphonates is associated with the occurrence of medication-related osteonecrosis of the jaw (MRONJ). Previous data reported the positive effects of Geranylgeraniol on different cell types treated with Bisphosphonates. Foregoing work done by our research group demonstrated the wound healing capacity of Fridericia chica (Bonpl.) L.G.Lohmann standardized ethanol extract. Herein in vitro cytoprotective synergistic effect of the association of F. chica extract associated with an enriched geranylgeraniol fraction on keratinocytes exposed to zoledronic acid is reported. An association of F. chica at 1 and 5 µg/mL with geranylgeraniol at 15 µg/mL, increased cell viability by 73.5% and 71.1%, respectively. This treatment did not increase tumor cells viability; whereas the clonogenic potential assessment showed that, the association with F. chica (5 µg/mL) reversed the effects of zoledronic acid on the cells. This study provides data for a potential treatment for MRONJ.
Databáze:	MEDLINE
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