Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.

Autor:	Rodriguez PE; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Silva AP; Departamento Laboratorio de Diagnóstico y Referencia, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., Miglietta EA; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Rall P; Instituto Nacional de Servicios Sociales para Jubilados y Pensionados (INSSJP-PAMI), Buenos Aires, Argentina., Pascuale CA; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Ballejo C; Departamento de Investigación Epidemiológica, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., López Miranda L; Departamento Laboratorio de Diagnóstico y Referencia, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., Ríos AS; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Ramis L; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Marro J; Departamento de Investigación Epidemiológica, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., Poncet V; Departamento Laboratorio de Diagnóstico y Referencia, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., Mazzitelli B; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS)-CONICET, Facultad de Medicina Universidad de Buenos Aires (UBA), Buenos Aires, Argentina., Salvatori M; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS)-CONICET, Facultad de Medicina Universidad de Buenos Aires (UBA), Buenos Aires, Argentina., Ceballos A; Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS)-CONICET, Facultad de Medicina Universidad de Buenos Aires (UBA), Buenos Aires, Argentina., Gonzalez Lopez Ledesma MM; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Ojeda DS; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Aguirre MF; Departamento de Investigación Epidemiológica, Instituto Nacional de Epidemiología 'Dr. Juan H. Jara', Mar del Plata, Argentina., Miragaya Y; Instituto Nacional de Servicios Sociales para Jubilados y Pensionados (INSSJP-PAMI), Buenos Aires, Argentina., Gamarnik AV; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina., Rossi AH; Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Sep 26; Vol. 13, pp. 992370. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.992370
Abstrakt:	The COVID-19 pandemic has particularly affected older adults residing in nursing homes, resulting in high rates of hospitalisation and death. Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. Sequential plasma samples were taken at different time points after vaccination. After completing the vaccination schedule, infection-naïve volunteers who received either Sputnik V or AZD1222 exhibited significantly higher specific anti-Spike IgG titers than those who received BBIBP-CorV. Strong correlation between anti-Spike IgG titers and neutralising activity levels was evidenced at all times studied (rho=0.7 a 0.9). Previous exposure to SARS-CoV-2 and age <80 years were both associated with higher specific antibody levels. No differences in neutralising capacity were observed for the infection-naïve participants in either gender or age group. Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. Neutralising capacity against Omicron was between 10-58 fold lower compared to ancestral B.1 for all vaccine platforms at 21 days post dose 2 and 180 days post dose 1. This work provides evidence about the humoral response and neutralising capacity elicited by vaccination of a vulnerable elderly population. This data could be useful for pandemic management in defining public health policies, highlighting the need to apply reinforcements after a complete vaccination schedule. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Rodriguez, Silva, Miglietta, Rall, Pascuale, Ballejo, López Miranda, Ríos, Ramis, Marro, Poncet, Mazzitelli, Salvatori, Ceballos, Gonzalez Lopez Ledesma, Ojeda, Aguirre, Miragaya, Gamarnik, Rossi, Laboratorio SeVa Group and PAMI Group.)
Databáze:	MEDLINE
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