Mammographic and Ultrasonographic Imaging Analysis for Neoadjuvant Chemotherapy Evaluation: Volume Reduction Indexes That Correlate With Pathological Complete Response.

Autor:	Mello JM; Radiology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, BRA., Sarvacinski F; Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BRA., Schaefer FC; Radiology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, BRA., Ercolani DS; Radiology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, BRA., Lobato NR; Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BRA., Martins YC; Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BRA., Zwetsch G; Radiology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, BRA., Bittelbrunn FP; Radiology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, BRA., Ferreira CF; Physiology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BRA., Damin AP; Gynecology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, BRA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Oct 05; Vol. 14 (10), pp. e29960. Date of Electronic Publication: 2022 Oct 05 (Print Publication: 2022).
DOI:	10.7759/cureus.29960
Abstrakt:	Introduction: We aimed to evaluate volume reduction in digital mammography (DM) and ultrasound (US) for neoadjuvant chemotherapy (NAC) evaluation, with breast cancer-specific survival and pathological complete response (pCR) associations. Methods: This is a retrospective observational cohort study analyzing recorded images in 122 selected subjects out of which 569 patients presented with advanced breast cancers. Spearman's correlation and generalized estimating equations (GEE) compared volume reduction on DM and US between pCR and non-pCR after NAC with post-surgical anatomopathology. Cox regression and Kaplan-Meier curves analyzed associations between cancer-specific survival, pCR, and volume reductions. Results: A total of 34.4% (N=42) obtained pCR and 65.6% (N=80) did not. Minimum percentage indexes needed to correlate with pCR over time were, at least, 28.9% for DM (p=0.006) and 10.36% for US (p=0.046), with high specificity (US=98%, DM=93%) but low sensitivity (US=7%, DM=18%). Positive predictive values were 82% (DM) and 86% (US) and negative predictive values were 37% (DM) and 36% (US). Cox regression and Kaplan-Meier curves demonstrated associations of breast cancer-specific survival with pCR (Cox regression coefficient {B}=0.209, CI 95%=0.048-0.914, p=0.038). Conclusions: At least 28.9% of volume reduction on DM and 10.36% of volume reduction on US are correlated with pCR. Furthermore, pCR was associated with breast cancer-specific survival after NAC in volumetric morphological imaging analysis. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Mello et al.)
Databáze:	MEDLINE
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