Protective Mechanisms of Nootropic Herb Shankhpushpi ( Convolvulus pluricaulis ) against Dementia: Network Pharmacology and Computational Approach.

Autor: Hannan MA; Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh., Sultana A; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh., Rahman MH; Department of Biotechnology and Genetic Engineering, Faculty of Life Sciences, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh., Al Mamun Sohag A; Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh., Dash R; Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea., Uddin MJ; ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh.; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea., Hossen MJ; Department of Animal Science, Patuakhali Science and Technology University, Dumki, Patuakhali 8602, Bangladesh., Moon IS; Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2022 Oct 03; Vol. 2022, pp. 1015310. Date of Electronic Publication: 2022 Oct 03 (Print Publication: 2022).
DOI: 10.1155/2022/1015310
Abstrakt: Convolvulus pluricaulis (CP), a Medhya Rasayana (nootropic) herb, is a major ingredient in Ayurvedic and Traditional Chinese formulae indicated for neurological conditions, namely, dementia, anxiety, depression, insanity, and epilepsy. Experimental evidence suggests various neuroactive potentials of CP such as memory-enhancing, neuroprotective, and antiepileptic. However, precise mechanisms underlying the neuropharmacological effects of CP remain unclear. The study, therefore, aimed at deciphering the molecular basis of neuroprotective effects of CP phytochemicals against the pathology of dementia disorders such as Alzheimer's (AD) and Parkinson's (PD) disease. The study exploited bioinformatics tools and resources, such as Cytoscape, DAVID (Database for annotation, visualization, and integrated discovery), NetworkAnalyst, and KEGG (Kyoto Encyclopedia of Genes and Genomes) database to investigate the interaction between CP compounds and molecular targets. An in silico analysis was also employed to screen druglike compounds and validate some selective interactions. ADME (absorption, distribution, metabolism, and excretion) analysis predicted a total of five druglike phytochemicals from CP constituents, namely, scopoletin, 4-hydroxycinnamic acid, kaempferol, quercetin, and ayapanin. In network analysis, these compounds were found to interact with some molecular targets such as prostaglandin G/H synthase 1 and 2 ( PTGS1 and PTGS2 ), endothelial nitric oxide synthase ( NOS3 ), insulin receptor ( INSR ), heme oxygenase 1 ( HMOX1 ), acetylcholinesterase ( ACHE ), peroxisome proliferator-activated receptor-gamma ( PPARG ), and monoamine oxidase A and B ( MAOA and MAOB ) that are associated with neuronal growth, survival, and activity. Docking simulation further confirmed interaction patterns and binding affinity of selected CP compounds with those molecular targets. Notably, scopoletin showed the highest binding affinity with PTGS1, NOS3, PPARG, ACHE, MAOA, MAOB, and TRKB, quercetin with PTGS2, 4-hydroxycinnamic acid with INSR, and ayapanin with HMOX1. The findings indicate that scopoletin, kaempferol, quercetin, 4-hydroxycinnamic acid, and ayapanin are the main active constituents of CP which might account for its memory enhancement and neuroprotective effects and that target proteins such as PTGS1, PTGS2, NOS3, PPARG, ACHE, MAOA, MAOB, INSR, HMOX1, and TRKB could be druggable targets against dementia.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2022 Md. Abdul Hannan et al.)
Databáze: MEDLINE
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