Emerging chemistry and biology in protein glutathionylation.

Autor: Kukulage DSK; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA., Matarage Don NNJ; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA., Ahn YH; Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA. Electronic address: ya426@drexel.edu.
Jazyk: angličtina
Zdroj: Current opinion in chemical biology [Curr Opin Chem Biol] 2022 Dec; Vol. 71, pp. 102221. Date of Electronic Publication: 2022 Oct 09.
DOI: 10.1016/j.cbpa.2022.102221
Abstrakt: Protein S-glutathionylation serves a regulatory role in proteins and modulates distinct biological processes implicated in health and diseases. Despite challenges in analyzing the dynamic and reversible nature of S-glutathionylation, recent chemical and biological methods have significantly advanced the field of S-glutathionylation, culminating in selective identification and detection, structural motif analysis, and functional studies of S-glutathionylation. This review will highlight emerging studies of protein glutathionylation, beginning by introducing biochemical tools that enable mass spectrometric identification and live-cell imaging of S-glutathionylation. Next, it will spotlight recent examples of S-glutathionylation regulating physiology and inflammation. Lastly, we will feature two emerging lines of glutathionylation research in cryptic cysteine glutathionylation and protein C-glutathionylation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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