Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models.

Autor:	Jeong H; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Woo Lee Y; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 13488, South Korea., Park IH; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea.; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, South Korea., Noh H; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, South Korea., Kim SH; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Kim J; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Jeon D; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Jang HJ; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 13488, South Korea., Oh J; Department of Microbiology, Yonsei University College of Medicine, Seoul 03722, South Korea., On D; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, South Korea.; Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and Brain Korea 21 FOUR Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea., Uhm C; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Cho K; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Oh H; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Yoon S; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, South Korea., Seo JS; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Kim JJ; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Seok SH; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, South Korea., Lee YJ; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, South Korea., Hong SM; Laboratory of Avian Diseases, Brain Korea 21 FOUR Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea., An SH; Laboratory of Avian Diseases, Brain Korea 21 FOUR Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea., Yeon Kim S; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam 13488, South Korea., Kim YB; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam 13488, South Korea., Hwang JY; Preclinical Research Center, Seoul National University Bundang Hospital, Seongnam 13488, South Korea., Lee HJ; Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam 13620, South Korea., Kim HB; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, South Korea., Jeong DG; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, South Korea., Song D; Department of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea., Song M; Science Unit, International Vaccine Institute, Seoul 08826, South Korea., Park MS; Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul 02841, South Korea., Choi KS; Laboratory of Avian Diseases, Brain Korea 21 FOUR Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea., Park JW; Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, South Korea., Seo JY; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Yun JW; Laboratory of Veterinary Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea., Shin JS; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea.; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, South Korea.; Department of Microbiology, Yonsei University College of Medicine, Seoul 03722, South Korea., Lee HY; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam 13488, South Korea.; Department of Nuclear Medicine, Seoul National University, College of Medicine, Seoul 03080, South Korea., Nam KT; Severance Biomedical Science Institute, Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea., Seong JK; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, South Korea.; Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and Brain Korea 21 FOUR Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea.; BIO-MAX Institute, Seoul National University, Seoul 08826, South Korea.; Interdisciplinary Program for Bioinformatics, Seoul National University, Seoul 08826, South Korea.
Jazyk:	angličtina
Zdroj:	Disease models & mechanisms [Dis Model Mech] 2022 Nov 01; Vol. 15 (11). Date of Electronic Publication: 2022 Nov 11.
DOI:	10.1242/dmm.049632
Abstrakt:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel coronavirus enters host cells via the respiratory tract, promoting the formation of severe pulmonary lesions and systemic disease. Few animal models can simulate the clinical signs and pathology of COVID-19 patients. Diverse preclinical studies using K18-hACE2 mice and Syrian golden hamsters, which are highly permissive to SARS-CoV-2 in the respiratory tract, are emerging; however, the systemic pathogenesis and cellular tropism of these models remain obscure. We intranasally infected K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2, and compared the clinical features, pathogenesis, cellular tropism and infiltrated immune-cell subsets. In K18-hACE2 mice, SARS-CoV-2 persistently replicated in alveolar cells and caused pulmonary and extrapulmonary disease, resulting in fatal outcomes. Conversely, in Syrian golden hamsters, transient SARS-CoV-2 infection in bronchial cells caused reversible pulmonary disease, without mortality. Our findings provide comprehensive insights into the pathogenic spectrum of COVID-19 using preclinical models. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2022. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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