Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study.

Autor: Valenzuela G; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Advanced Interdisciplinary Rehabilitation Register (AIRR) - COVID-19 Working Group, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Alarcón-Andrade G; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Schulze-Schiapacasse C; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Rodríguez R; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Clínico Red Salud UC-Christus, Santiago, Chile., García-Salum T; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Advanced Interdisciplinary Rehabilitation Register (AIRR) - COVID-19 Working Group, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Pardo-Roa C; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Advanced Interdisciplinary Rehabilitation Register (AIRR) - COVID-19 Working Group, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Levican J; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Serrano E; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Avendaño MJ; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Gutiérrez M; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Dr. Sótero del Río, Santiago, Chile., Godoy L; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Dr. Sótero del Río, Santiago, Chile., Céspedes P; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Dr. Sótero del Río, Santiago, Chile., Bermudez S; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Dr. Sótero del Río, Santiago, Chile., Aravena J; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Nicolaides I; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Martínez E; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Gómez-Canobbio C; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Jofré M; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Salinas A; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Depaoli D; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Loza C; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Muñoz A; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Ormazábal N; Centro de Responsabilidad de Peditaría, Hospital Clínico La Florida, Santiago, Chile., Manzur D; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Clínico Red Salud UC-Christus, Santiago, Chile., Barriga J; Division of Pediatrics, Pontificia Universidad Católica de Chile, Hospital Clínico Red Salud UC-Christus, Santiago, Chile., Almonacid LI; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Poblete-Cárdenas E; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Salinas E; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Advanced Interdisciplinary Rehabilitation Register (AIRR) - COVID-19 Working Group, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Muñoz-Marcos A; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Barja S; Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Catolica de Chile, Hospital Josefina Martínez, Santiago, Chile., Medina RA; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Advanced Interdisciplinary Rehabilitation Register (AIRR) - COVID-19 Working Group, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jazyk: angličtina
Zdroj: Pediatric obesity [Pediatr Obes] 2023 Feb; Vol. 18 (2), pp. e12980. Date of Electronic Publication: 2022 Oct 12.
DOI: 10.1111/ijpo.12980
Abstrakt: Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined.
Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients.
Methods: An observational study was conducted in three tertiary hospitals, including paediatric hospitalized patients with a confirmatory SARS-CoV-2 RT-PCR from March 2020 to December 2021. Obesity was defined according to WHO 2006 (0-2 years) and CDC 2000 (2-20 years) growth references. Short-term outcomes were intensive care unit admission, ventilatory support, superinfections, acute kidney injury, and mortality. Neurological, respiratory, and cardiological symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms were considered as post-acute sequalae. Adjusted linear, logistic regression and generalized estimating equations models were performed.
Results: A total of 216 individuals were included, and 67 (31.02%) of them had obesity. Obesity was associated with intensive care unit admission (aOR = 5.63, CI95% 2.90-10.94), oxygen requirement (aOR = 2.77, CI95% 1.36-5.63), non-invasive ventilatory support (aOR = 6.81, CI95% 2.11-22.04), overall superinfections (aOR = 3.02 CI95% 1.45-6.31), and suspected bacterial pneumonia (aOR = 3.00 CI95% 1.44-6.23). For post-acute sequalae, obesity was associated with dyspnea (aOR = 9.91 CI95% 1.92-51.10) and muscle weakness (aOR = 20.04 CI95% 2.50-160.65).
Conclusions: In paediatric hospitalized patients with COVID-19, severe short-term outcomes and post-acute sequelae are associated with obesity. Recognizing obesity as a key comorbidity is essential to develop targeted strategies for prevention of COVID-19 complications in children.
(© 2022 World Obesity Federation.)
Databáze: MEDLINE
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