| Autor: |
Laffon E; CHU de Bordeaux, Bordeaux, France.; Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France., Marthan R; CHU de Bordeaux, Bordeaux, France.; Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.; INSERM U-1045, Centre de Recherche Cardio-Thoracique de Bordeaux, Bordeaux, France. |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2023 Feb; Vol. 38 (1), pp. 74-76. Date of Electronic Publication: 2022 Oct 10. |
| DOI: |
10.1089/cbr.2022.0046 |
| Abstrakt: |
Two independent equations were recently proposed for estimating 177 Lu-cetuximab cumulative activity, in a preclinical situation, from an initial 64 Cu-cetuximab diagnostic scan acquired at peak time of decay-uncorrected ( t peak-uncorr ) or decay-corrected ( t peak-corr ) time-activity curve of trapped 64 Cu-cetuximab, respectively. The standard uptake ratio (SUR) measured at t peak-uncorr or t peak-corr turned out to be a key metric in each equation, respectively. However, acquiring the diagnostic scan at t peak-uncorr or t peak-corr might be a limitation of the proposed method. Therefore, in an attempt to overcome this limitation, this note aims at theoretically investigating whether SUR( t peak-uncorr ) and/or SUR( t peak-corr ) could be derived from a diagnostic scan acquired at any time postinjection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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