Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa.

Autor:	Ozeki T; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Abe H; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Ushijima Y; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan., Nze-Nkogue C; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Akomo-Okoue EF; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Ella GWE; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Koumba LBM; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Nso BCBB; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Mintsa-Nguema R; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Makouloutou-Nzassi P; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Makanga BK; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Nguelet FLM; Institut de Recherche en Ecologie Tropicale (IRET), Libreville BP13354, Gabon., Ondo GN; Centre de Recherche Médicales de Lambaréné (CERMEL), Lambaréné BP242, Gabon., Mbadinga MJVM; Centre de Recherche Médicales de Lambaréné (CERMEL), Lambaréné BP242, Gabon., Igasaki Y; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan., Okada S; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Hirano M; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Yoshii K; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Lell B; Centre de Recherche Médicales de Lambaréné (CERMEL), Lambaréné BP242, Gabon.; University of Tübingen, Tübingen 72072, Germany.; Medical University of Vienna, Vienna 1090, Austria., Bonney LC; United Kingdom Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JZ, UK., Hewson R; United Kingdom Health Security Agency (UKHSA), Porton Down, Salisbury SP4 0JZ, UK., Kurosaki Y; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan., Yasuda J; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki 852-8523, Japan.
Jazyk:	angličtina
Zdroj:	The Journal of general virology [J Gen Virol] 2022 Oct; Vol. 103 (10).
DOI:	10.1099/jgv.0.001796
Abstrakt:	In Africa, several emerging zoonotic viruses have been transmitted from small mammals such as rodents and shrews to humans. Although no clinical cases of small mammal-borne viral diseases have been reported in Central Africa, potential zoonotic viruses have been identified in rodents in the region. Therefore, we hypothesized that there may be unrecognized zoonotic viruses circulating in small mammals in Central Africa. Here, we investigated viruses that have been maintained among wild small mammals in Gabon to understand their potential risks to humans. We identified novel orthonairoviruses in 24.6 % of captured rodents and shrews from their kidney total RNA samples. Phylogenetic analysis revealed that the novel viruses, Lamusara virus (LMSV) and Lamgora virus, were closely related to Erve virus, which was previously identified in shrews of the genus Crocidura and has been suspected to cause neuropathogenic diseases in humans. Moreover, we show that the LMSV ovarian tumour domain protease, one of the virulence determination factors of orthonairoviruses, suppressed interferon signalling in human cells, suggesting the possible human pathogenicity of this virus. Taken together, our study demonstrates the presence of novel orthonairoviruses that may pose unrecognized risks of viral disease transmission in Gabon.
Databáze:	MEDLINE
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