Cobalt Ferrite Nanoparticle's Safety in Biomedical and Agricultural Applications: A Review of Recent Progress.

Autor:	Shakil MS; Department of Mathematics and Natural Sciences, Brac University, 66 Mohakhali, Dhaka 1212, Bangladesh.; Department of Pharmacology & Toxicology, University of Otago, 362 Leith St, North Dunedin, Dunedin 9016, New Zealand., Bhuiya MS; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh., Morshed MR; Department of Biochemistry and Molecular Biology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh., Babu G; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh., Niloy MS; Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh., Hossen MS; Department of Biochemistry and Molecular Biology, Primeasia University, Banani, Dhaka 1213, Bangladesh., Islam MA; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (15), pp. 1756-1775.
DOI:	10.2174/0929867329666221007113951
Abstrakt:	Cobalt ferrite nanoparticles (CFN) have drawn attention as a theranostic agent. Unique physicochemical features of CFN and magnetic properties make CFN an outstanding candidate for biomedical, agricultural, and environmental applications. The extensive use of CFN may result in intentional inoculation of humans for disease diagnosis and therapeutic purposes or unintentional penetration of CFN via inhalation, ingestion, adsorption, or other means. Therefore, understanding the potential cytotoxicity of CFN may pave the way for their future biomedical and agricultural applications. This review scrutinized CFN biocompatibility, possible effects, and cytotoxic mechanisms in different biological systems. Literature indicates CFN toxicity is linked with their size, synthesizing methods, coating materials, exposure time, route of administration, and test concentrations. Some in vitro cytotoxicity tests showed misleading results of CFN potency; this might be due to the interaction of CFN with cytotoxicity assay regents. To date, published research indicates that the biocompatibility of CFN outweighed its cytotoxic effects in plant or animal models, but the opposite outcomes were observed in aquatic Zebrafish. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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