Acute sleep deprivation disrupts emotion, cognition, inflammation, and cortisol in young healthy adults.

Autor:	Thompson KI; Department of Psychology and Neuroscience, Nova Southeastern University, Davie, FL, United States.; Department of Clinical and School Psychology, Nova Southeastern University, Davie, FL, United States., Chau M; Department of Psychology and Neuroscience, Nova Southeastern University, Davie, FL, United States., Lorenzetti MS; Icahn School of Medicine at Mount Sinai, New York City, NY, United States., Hill LD; Department of Psychology, Florida International University, Miami, FL, United States., Fins AI; Department of Clinical and School Psychology, Nova Southeastern University, Davie, FL, United States., Tartar JL; Department of Psychology and Neuroscience, Nova Southeastern University, Davie, FL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2022 Sep 23; Vol. 16, pp. 945661. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).
DOI:	10.3389/fnbeh.2022.945661
Abstrakt:	Chronic sleep deprivation has been demonstrated to diminish cognitive performance, alter mood states, and concomitantly dysregulate inflammation and stress hormones. At present, however, there is little understanding of how an acute sleep deprivation may collectively affect these factors and alter functioning. The present study aimed to determine the extent to which 24-h of sleep deprivation influences inflammatory cytokines, stress hormones, cognitive processing across domains, and emotion states. To that end, 23 participants (mean age = 20.78 years, SD = 2.87) filled out clinical health questionnaires measured by the Pittsburgh Sleep Quality Index, Morningness Eveningness Questionnaire, and Center for Epidemiological Studies Depression Scale. Actigraph was worn for seven days across testing to record sleep duration. At each session participants underwent a series of measures, including saliva and blood samples for quantification of leptin, ghrelin, IL-1β, IL-6, CRP, and cortisol levels, they completed a cognitive battery using an iPad, and an emotion battery. We found that an acute sleep deprivation, limited to a 24 h period, increases negative emotion states such as anxiety, fatigue, confusion, and depression. In conjunction, sleep deprivation results in increased inflammation and decreased cortisol levels in the morning, that are accompanied by deficits in vigilance and impulsivity. Combined, these results suggest that individuals who undergo 24 h sleep deprivation will induce systemic alterations to inflammation and endocrine functioning, while concomitantly increasing negative emotions. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Thompson, Chau, Lorenzetti, Hill, Fins and Tartar.)
Databáze:	MEDLINE
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