Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review.

Autor:	Haseeb A; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Faidah HS; Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Alghamdi S; Department of Clinical Pharmacy, Faculty of Clinical Pharmacy, Al Baha University, Al Baha, Saudi Arabia., Alotaibi AF; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Elrggal ME; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Mahrous AJ; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Abuhussain SSA; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Obaid NA; Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Algethamy M; Department of Infection Prevention and Control Program, Alnoor Specialist Hospital, Makkah, Saudi Arabia., AlQarni A; Infectious Diseases Department, Alnoor Specialist Hospital, Makkah, Saudi Arabia., Khogeer AA; Plan and Research Department, General Directorate of Health Affairs of Makkah Region, Ministry of Health, Makkah, Saudi Arabia.; Medical Genetics Unit, Maternity and Children Hospital, Makkah Healthcare Cluster, Ministry of Health, Makkah, Saudi Arabia., Saleem Z; Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya Univrsity, Multan, Pakistan., Iqbal MS; Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia., Ashgar SS; Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Radwan RM; Pharmaceutical Care Department, Alnoor Specialist Hospital, Ministry of Health, Makkah, Saudi Arabia., Mutlaq A; General Department of Pharmaceutical Care, Ministry of Health, Riyadh, Saudi Arabia., Fatani N; King Abdulaziz University, Jeddah, Saudi Arabia., Sheikh A; Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 Sep 21; Vol. 13, pp. 964005. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.964005
Abstrakt:	Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh.)
Databáze:	MEDLINE
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