Comparison of embryo implantation potential between time-lapse incubators and standard incubators: a randomized controlled study.

Autor: Zhang XD; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China., Zhang Q; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China., Han W; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China., Liu WW; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China., Shen XL; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China., Yao GD; IVF Clinical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, China., Shi SL; IVF Clinical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, China., Hu LL; IVF Clinical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, China., Wang SS; Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing Jiangsu, China., Wang JX; Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing Jiangsu, China., Zhou JJ; Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing Jiangsu, China., Kang WW; Department of Obstetrics and Gynaecology, Tangdu Hospital, Air Force Medical University, Xi-an Shanxi, China., Zhang HD; Department of Obstetrics and Gynaecology, Tangdu Hospital, Air Force Medical University, Xi-an Shanxi, China., Luo C; IVF Clinical Center, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China., Yu Q; IVF Clinical Center, Peking Union Medical College Hospital, Dongcheng District Beijing, China., Liu RZ; IVF Clinical Center, The First Bethune Hospital of Jilin University, Changchun Jilin, China., Sun YP; IVF Clinical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, China. Electronic address: syp2008@vip.sina.com., Sun HX; Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing Jiangsu, China. Electronic address: stevensun@163.com., Wang XH; Department of Obstetrics and Gynaecology, Tangdu Hospital, Air Force Medical University, Xi-an Shanxi, China. Electronic address: wangxh-99919@163.com., Quan S; IVF Clinical Center, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, China. Electronic address: quansong@smu.edu.cn., Huang GN; Chongqing Key Laboratory of Human Embryo Engineering Chongqing, China; Center for Reproductive Medicine, Reproductive and Genetic Institute, Women and Children's Hospital of Chongqing Medical University Chongqing, China. Electronic address: gnhuang217@sina.com.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2022 Nov; Vol. 45 (5), pp. 858-866. Date of Electronic Publication: 2022 Jun 28.
DOI: 10.1016/j.rbmo.2022.06.017
Abstrakt: Research Question: What are the potential clinical benefits of embryo culture and assessment in a time-lapse incubator compared with a standard incubator using static assessment?
Design: This large multicentre, single-blinded, randomized controlled study included 1224 participants randomly assigned (1:1) to the time-lapse or standard incubator group. In all patients one or two embryos were transferred on day 3. The primary outcome was the implantation rate in the first embryo transfer cycle. Secondary outcomes included the cumulative implantation rate, live birth rate in the first embryo transfer cycle and cumulative live birth rate.
Results: Among 1224 participants recruited, 1182 underwent embryo transfer. The number of successfully implanted embryos in the first transfer cycle was significantly higher in the time-lapse incubator group (time-lapse group: 52.35%, standard incubator group: 47.11%, P = 0.014). The implantation rate in the first embryo transfer cycle was still significantly higher in the time-lapse group than the standard incubator group after adjusting for age, body mass index, medical centre and embryo status (relative risk 1.11, 95% confidence interval 1.02-1.20, P = 0.020). However, the cumulative implantation rate, live birth rate in the first embryo transfer cycle and cumulative live birth rate were not statistically different between the groups.
Conclusions: The implantation rate in the first embryo transfer cycle was significantly improved in the time-lapse group, but the effect of the time-lapse system on the cumulative implantation rate or cumulative live birth rate was not significant. The embryo assessment method offered by time-lapse systems rather than an undisturbed environment may play an important role in improving the implantation rate in the first embryo transfer cycle. These results are only applicable to young patients.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE