Asenapine, an atypical antipsychotic, blocks voltage-gated potassium channels in rabbit coronary artery smooth muscle cells.
Autor: | Seo MS; Department of Physiology, Konkuk University School of Medicine, Chungju, 27478, South Korea. Electronic address: seoms@kangwon.ac.kr., Kang M; Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., An JR; Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Heo R; Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Jung WK; Department of Biomedical Engineering, And Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, South Korea., Choi IW; Department of Microbiology, College of Medicine, Inje University, Busan, 48516, South Korea., Han ET; Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Han JH; Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Chun W; Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Park WS; Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea. Electronic address: parkws@kangwon.ac.kr. |
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Jazyk: | angličtina |
Zdroj: | European journal of pharmacology [Eur J Pharmacol] 2022 Nov 05; Vol. 934, pp. 175318. Date of Electronic Publication: 2022 Oct 07. |
DOI: | 10.1016/j.ejphar.2022.175318 |
Abstrakt: | We investigated the effect of asenapine, a commonly used atypical antipsychotic, on voltage-dependent K + (Kv) channels in rabbit coronary artery smooth muscle cells. Asenapine inhibited the Kv current in a concentration-dependent manner, with an half-inhibitory concentration (IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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