Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Other Gastrointestinal Pathology in the Cystic Fibrosis Patient.
| Autor: | Tobias J; 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA., Tillotson M; 2314 Northeast Multnomah Street, Portland, OR 97232, USA., Maloney L; 2314 Northeast Multnomah Street, Portland, OR 97232, USA., Fialkowski E; Pediatric General Surgery, Oregon Health and Science University, Portland, OR, USA. Electronic address: fialkows@ohsu.edu. |
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| Jazyk: | angličtina |
| Zdroj: | The Surgical clinics of North America [Surg Clin North Am] 2022 Oct; Vol. 102 (5), pp. 873-882. Date of Electronic Publication: 2022 Sep 07. |
| DOI: | 10.1016/j.suc.2022.07.016 |
| Abstrakt: | Cystic fibrosis is an autosomal-recessive defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene located on chromosome 7 that affects 1 in 2500 live White births. Defects in the gene lead to abnormally thick secretions causing chronic obstruction in the respiratory and gastrointestinal tracts. Common gastrointestinal pathology in children with cystic fibrosis includes meconium ileus in infancy and distal intestinal obstruction syndrome in childhood and exocrine pancreatic insufficiency, constipation, and rectal prolapse. This article describes the presentation, diagnosis, and management of these conditions in patients with cystic fibrosis, from birth to adulthood. Competing Interests: Disclosure The authors have nothing to disclose. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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