European consensus for the diagnosis of MCI and mild dementia: Preparatory phase.

Autor:	Festari C; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Massa F; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Cotta Ramusino M; Unit of Behavioral Neurology, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Gandolfo F; Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Galliera Hospital, Genova, Italy., Nicolosi V; UOC Neurologia, Ospedale Magalini (ULSS 9 - Veneto), Villafranca di Verona (VR), Italy., Orini S; Alzheimer's Unit - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; Dipartimento di Scienze Cliniche e Sperimentali, Università degli Studi di Brescia, Brescia, Italy., Aarsland D; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Centre for Age-Related Diseases, Stavanger University Hospital, Stavanger, Norway.; European DLB Consortium., Agosta F; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; European Academy of Neurology., Babiloni C; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.; Hospital San Raffaele of Cassino, Cassino (FR), Italy.; Europe, Middle East and Africa Chapter of the International Federation of Clinical Neurophysiology., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Borroni B; Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili, Brescia, Italy.; European FTLD network., Cappa S; Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy.; Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy.; Federation of the European Societies of Neuropsychology., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), ICM, Salpetriere Hospital, AP-HP, University Paris 6, Paris, France., Frederiksen KS; European Academy of Neurology.; Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Froelich L; Department of Geriatric Psychiatry, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.; European Alzheimer Disease Consortium., Garibotto V; NIMTLab, Faculty of Medicine, University of Geneva, Switzerland.; Division of Nuclear Medicine and Molecular Imaging, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.; Center for Biomedical Imaging, CIBM, Geneva, Switzerland.; European Association of Nuclear Medicine., Georges J; Alzheimer Europe., Haliassos A; ESEAP-Proficiency Testing Scheme for Clinical Laboratories, Athens, Greece.; International Federation of Clinical Chemistry., Hansson O; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmo, Sweden., Jessen F; European Alzheimer Disease Consortium.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Kamondi A; Europe, Middle East and Africa Chapter of the International Federation of Clinical Neurophysiology.; Department of Neurology, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary., Kessels RPC; Federation of the European Societies of Neuropsychology.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.; Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.; Department of Medical Psychology and Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands., Morbelli S; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Dept of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., O'Brien JT; European DLB Consortium.; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK., Otto M; European FTLD network.; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany., Perret-Liaudet A; International Federation of Clinical Chemistry.; Laboratory of Neurobiology, Department of Biochemistry and Molecular Biology, Hospices civils de Lyon; Research and Resources Memory Centre, Lyon, France.; BioRan Team, Centre de Recherche en Neurosciences de Lyon, CNRS UMR5292, INSERM U1028, Lyon, France., Pizzini FB; Verona University Hospital, Verona University, Dept. of Diagnostic and Public Health, Verona, Italy.; European Union of Medical Specialists., Ritchie CW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Brain Health Scotland, Edinburgh, UK., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Vandenbulcke M; Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Geriatric Psychiatry, University Psychiatric Centre KU Leuven, Leuven, Belgium.; European Association of Geriatric Psychiatry., Vanninen R; European Union of Medical Specialists.; University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Verhey F; European Association of Geriatric Psychiatry.; Department of Psychiatry and Neuropsychology/Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vernooij MW; Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; European Society of Neuroradiology., Yousry T; European Society of Neuroradiology.; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, UK., Van Der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Nobili F; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Frisoni GB; Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.; Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 May; Vol. 19 (5), pp. 1729-1741. Date of Electronic Publication: 2022 Oct 09.
DOI:	10.1002/alz.12798
Abstrakt:	Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results: We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion: The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers' use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights: Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues. (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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