Metabolic connectivity is associated with seizure outcome in surgically treated temporal lobe epilepsies: A 18 F-FDG PET seed correlation analysis.

Autor:	Doyen M; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France; Université de Lorraine, IADI, INSERM U1254, F-54000 Nancy, France. Electronic address: matthieu.doyen@univ-lorraine.fr., Chawki MB; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France. Electronic address: momodestains@yahoo.fr., Heyer S; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France. Electronic address: s.heyer@chru-nancy.fr., Guedj E; Aix Marseille Univ, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Nuclear Medicine Department, F-13000 Marseille, France. Electronic address: eric.guedj@univ-amu.fr., Roch V; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France. Electronic address: v.roch@chru-nancy.fr., Marie PY; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France; Université de Lorraine, INSERM, DCAC, Nancy, France. Electronic address: py.marie@chru-nancy.fr., Tyvaert L; Université de Lorraine, CRAN UMR 7039, Nancy, France; Department of Neurology, CHRU Nancy, National Reference Center for Rare Epilepsies, F-54000 Nancy, France. Electronic address: l.tyvaert@chru-nancy.fr., Maillard L; Université de Lorraine, CRAN UMR 7039, Nancy, France; Department of Neurology, CHRU Nancy, National Reference Center for Rare Epilepsies, F-54000 Nancy, France. Electronic address: l.maillard@chru-nancy.fr., Verger A; Université de Lorraine, Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, F-54000 Nancy, France; Université de Lorraine, IADI, INSERM U1254, F-54000 Nancy, France. Electronic address: a.verger@chru-nancy.fr.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2022; Vol. 36, pp. 103210. Date of Electronic Publication: 2022 Sep 24.
DOI:	10.1016/j.nicl.2022.103210
Abstrakt:	18 F-FDG PET provides high sensitivity for the pre-surgical assessment of drug-resistant temporal lobe epilepsy (TLE). However, little is known about the metabolic connectivity of epileptogenic networks involved. This study therefore aimed to evaluate the association between metabolic connectivity and seizure outcome in surgically treated TLE. Methods: The study included 107 right-handed patients that had undergone a presurgical interictal 18 F-FDG PET assessment followed by an anterior temporal lobectomy and were classified according to seizure outcome 2 years after surgery. Metabolic connectivity was evaluated by seed correlation analysis in left and right epilepsy patients with a Class Engel IA or > IA outcome and compared to age-, sex- and handedness-matched healthy controls. Results: Increased metabolic connectivity was observed in the >IA compared to the IA group within the operated temporal lobe (respective clusters of 7.5 vs 3.3 cm 3 and 2.6 cm 3 vs 2.2 cm 3 in left and right TLE), and to a lower extent with the contralateral temporal lobe (1.2 vs 0.7 cm 3 and 1.7 cm 3 vs 0.7 cm 3 in left and right TLE). Seed correlations provided added value for the estimated individual performance of seizure outcome over the group comparisons in left TLE (AUC of 0.74 vs 0.67). Conclusion: Metabolic connectivity is associated with outcome in surgically treated TLE with a strengthened epileptogenic connectome in patients with non-free-seizure outcomes. The added value of seed correlation analysis in left TLE underlines the importance of evaluating metabolic connectivity in network related diseases. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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