Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors.

Autor: Blet A; Université Paris Cité, Department of Anesthesiology, Critical Care and Burn Unit, INSERM, UMR-S 942, MASCOT, FCRIN INI-CRCT, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, Paris, France., McNeil JB; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University School of Medicine, Nashville, Vanderbilt, TN, USA., Josse J; Université de Montpellier, IDESP-Institut Desbrest d'Épidémiologie et de Santé Publique, PREMEDICAL - Médecine de Précision Par Intégration de Données et Inférence Causale, CRISAM- Inria Sophia Antipolis - Méditerranée, Montpellier, France., Cholley B; Université Paris Cité, INSERM UMR_S 1140 'Innovations Thérapeutiques en Hémostase', 75006, Paris, France.; Hôpital Européen Georges Pompidou, AP-HP, 75015, Paris, France., Cinotti R; University of Nantes, Department of Anesthesia and Critical Care, Hôtel Dieu, Intensive Care Unit, University Hospital of Nantes, Nantes, France., Cotter G; Momentum Research, Inc., Chapel Hill, NC, 27517, USA., Dauvergne A; Université Paris Cité, Department of Biochemistry, Assistance Publique - Hôpitaux de Paris, Hôpital Beaujon, Clichy, France., Davison B; Momentum Research, Inc., Chapel Hill, NC, 27517, USA., Duarte K; Université de Lorraine, INSERM 1433 CIC-P CHRU de Nancy, Inserm U1116 and FCRIN INI-CRCT, Nancy, France., Duranteau J; Université Paris-Sud, Anesthesia and Intensive Care Department, Assistance Publique Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France., Fournier MC; Université Paris Cité, Department of Anesthesiology, Critical Care and Burn Unit, INSERM, UMR-S 942, MASCOT, FCRIN INI-CRCT, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, Paris, France., Gayat E; Université Paris Cité, Department of Anesthesiology, Critical Care and Burn Unit, INSERM, UMR-S 942, MASCOT, FCRIN INI-CRCT, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, Paris, France., Jaber S; Université de Montpellier, Department of Anesthesia and Intensive Care Unit, PhyMedExp, INSERM U1046, CNRS UMR, 9214, CHRU de Montpellier, Hôpital Saint Eloi, Montpellier, France., Lasocki S; Université d'Angers, Department of Anesthesia and Intensive Care Unit, CHU d'Angers, Angers, France., Merkling T; Université de Lorraine, INSERM 1433 CIC-P CHRU de Nancy, Inserm U1116 and FCRIN INI-CRCT, Nancy, France., Peoc'h K; Université Paris Cité, Department of Biochemistry, CRI INSERM UMR1149, HUPNVS, Assistance Publique - Hôpitaux de Paris, Paris, France., Mayer I; Institute for Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany., Sadoune M; Université Paris Cité, Department of Anesthesiology, Critical Care and Burn Unit, INSERM, UMR-S 942, MASCOT, FCRIN INI-CRCT, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, Paris, France., Laterre PF; Intensive Care Unit, Clinique Universitaire St Luc UCL, Brussels, Belgium., Sonneville R; Université Paris Cité, Department of Intensive Care Medicine, INSERM UMR1148, HUPNVS, Assistance Publique - Hôpitaux de Paris, Paris, France., Ware L; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University School of Medicine, Nashville, Vanderbilt, TN, USA., Mebazaa A; Université Paris Cité, Department of Anesthesiology, Critical Care and Burn Unit, INSERM, UMR-S 942, MASCOT, FCRIN INI-CRCT, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, Paris, France. alexandre.mebazaa@aphp.fr., Kimmoun A; Université de Lorraine, CHRU de Nancy, Intensive Care Medicine Babois, INSERM U1116, FCRIN INI-CRCT, Nancy, France.
Jazyk: angličtina
Zdroj: Critical care (London, England) [Crit Care] 2022 Oct 07; Vol. 26 (1), pp. 307. Date of Electronic Publication: 2022 Oct 07.
DOI: 10.1186/s13054-022-04171-1
Abstrakt: Background: Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mortality.
Methods: FROG-ICU, a multicenter European study enrolling all-comers critical care patients was analyzed (n = 1551). Association between red blood cells transfusion administered in intensive care unit and 1-year mortality in critical care survivors was analyzed using an augmented inverse probability of treatment weighting-augmented inverse probability of censoring weighting method to control confounders.
Results: Among the 1551 ICU-survivors, 42% received at least one unit of red blood cells while in intensive care unit. Patients in the transfusion group had greater severity scores than those in the no-transfusion group. According to unweighted analysis, 1-year post-critical care mortality was greater in the transfusion group compared to the no-transfusion group (hazard ratio (HR) 1.78, 95% CI 1.45-2.16). Weighted analyses including 40 confounders, showed that transfusion remained associated with a higher risk of long-term mortality (HR 1.21, 95% CI 1.06-1.46).
Conclusions: Our results suggest a high incidence of in-ICU RBC transfusion and that in-ICU transfusion is associated with a higher 1-year mortality among in-ICU survivors. Trial registration ( NCT01367093 ; Registered 6 June 2011).
(© 2022. The Author(s).)
Databáze: MEDLINE
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