Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.

Autor: Haigh SM; Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA. shaigh@unr.edu.; Department of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA. shaigh@unr.edu., Van Key L; Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA., Brosseau P; Department of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Eack SM; School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA., Leitman DI; National Institute of Mental Health, Bethesda, MD, USA., Salisbury DF; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Behrmann M; Department of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Journal of autism and developmental disorders [J Autism Dev Disord] 2023 Dec; Vol. 53 (12), pp. 4856-4871. Date of Electronic Publication: 2022 Oct 07.
DOI: 10.1007/s10803-022-05771-0
Abstrakt: Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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