Choroidal vascularity index and choroidal thickness: potential biomarkers in retinitis pigmentosa.

Autor: Abdolrahimzadeh S; Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy. solmaz.abdolrahimzadeh@uniroma1.it.; St. Andrea Hospital, Rome, Via di Grottarossa 1035/1039, Rome, 00189, Italy. solmaz.abdolrahimzadeh@uniroma1.it., Di Pippo M; Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy., Ciancimino C; Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy., Di Staso F; Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, Italy., Lotery AJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK. a.j.lotery@soton.ac.uk.
Jazyk: angličtina
Zdroj: Eye (London, England) [Eye (Lond)] 2023 Jun; Vol. 37 (9), pp. 1766-1773. Date of Electronic Publication: 2022 Oct 07.
DOI: 10.1038/s41433-022-02270-5
Abstrakt: Retinitis pigmentosa (RP) is the commonest inherited retinal dystrophy. It is characterized by progressive photoreceptor degeneration and cell death and ongoing neuronal and vascular impairment. In recent years, pathophysiological alterations of the choroid have begun to be appreciated in RP. Thus, representing a potential diagnostic and therapeutic biomarker. In particular, choroidal thickness and the choroidal vascularity index can be used to understand the pathogenesis of disease and evaluate new therapeutic possibilities. Photoreceptor changes seen in eyes with RP are directly correlated to a decrease of choroidal flow, leading to a strong association between relative choroidal ischemia and visual impairment. In this review we analyse the literature on choroidal thickness and choroidal vascularity index in patients with RP and assess whether these markers may reflect progression of disease from an anatomical and functional point of view.
(© 2022. The Author(s).)
Databáze: MEDLINE
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