[Stimulating effect of cocaine in rats with different levels of blood esterase activity].
| Autor: | Marusov IV, Mkheidze MO |
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| Jazyk: | ruština |
| Zdroj: | Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1987 Aug; Vol. 104 (8), pp. 183-5. |
| Abstrakt: | It was shown in experiments on male random-bred rats that motor stimulating effect of cocaine (10 mg/kg, intraperitoneally) was dependent on the spectrum of blood serum esterase activity. The determination of esterase spectrum was performed by disc-electrophoresis in 7.5% PAAG (50-75 gamma of protein per gel), with enzyme activity estimated using alpha-naphthylacetate. Proserine (10(-5) M) and butyrylthiocholine controls were used. Motor stimulating effect of cocaine in animals with 3 esterase fractions was 3 times higher than in animals with 4 enzyme fractions. |
| Databáze: | MEDLINE |
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