Vitamin D binding protein gene polymorphisms are associated with lower plasma 25-hydroxy-cholecalciferol concentrations in Ethiopian lactating women.

Autor: Hart MD; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74078, USA., Girma M; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74078, USA; School of Nutrition, Food Science, and Technology, Hawassa University, Hawassa, Ethiopia., Strong MD; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74078, USA., Tadesse BT; Department of Pediatrics, Hawassa University, Hawassa, Ethiopia., Taddesse BM; School of Nutrition, Food Science, and Technology, Hawassa University, Hawassa, Ethiopia., Alemayehu FR; School of Nutrition, Food Science, and Technology, Hawassa University, Hawassa, Ethiopia., Stoecker BJ; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74078, USA. Electronic address: barbara.stoecker@okstate.edu., Chowanadisai W; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74078, USA. Electronic address: winyoo.chowanadisai@okstate.edu.
Jazyk: angličtina
Zdroj: Nutrition research (New York, N.Y.) [Nutr Res] 2022 Nov; Vol. 107, pp. 86-95. Date of Electronic Publication: 2022 Sep 14.
DOI: 10.1016/j.nutres.2022.09.003
Abstrakt: Ethiopian women have been reported to have low plasma 25-hydroxy-cholecalciferol (25(OH)D) concentrations despite an abundance of sunshine. Low dietary vitamin D intake, limited skin exposure to sun, and genetics are among factors suggested to affect vitamin D status in this population. In this study (Clinical Trial NCT02210884), we hypothesized that polymorphisms in the vitamin D binding protein (VDBP) gene (rs7041, rs4588) are associated with reduced plasma 25(OH)D concentrations in Ethiopian women. Lactating Ethiopian women (n = 110) were randomly assigned to weekly administration of vitamin D3 (15,000 IU) or a placebo. Plasma 25(OH)D was measured at baseline (within 2 weeks of delivery, before supplementation) and at 3, 6, and 12 months after delivery. Associations between VDBP polymorphism status for rs7041 and rs4588 and plasma 25(OH)D were determined by analysis of variance and multiple linear and logistic regressions. Multiple linear regression with maternal age as a covariate revealed that rs7041 is associated with reduced plasma 25(OH)D (P = .021) and more risk alleles at rs7041 and rs4588 are associated with reduced plasma 25(OH)D (P = .017). Logistic regression models for vitamin D insufficiency showed that additional risk alleles for rs7041 and rs4588 are associated with increased odds ratios (OR = 1.66; 95% CI, 1.10-2.62; P = .019) for plasma 25(OH)D below 40 nmol/L. Supplementation increased plasma 25(OH)D at 3 months in women with fewer risk alleles and across all genotypes at 6 and 12 months. VDBP polymorphisms may contribute to vitamin D insufficiency in Ethiopian lactating women. Furthermore, VDBP polymorphisms may blunt short-term responses to vitamin D supplementation and require longer periods of intervention.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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