Characterising the spatial and oscillatory unfolding of Theory of Mind in adults using fMRI and MEG.

Autor:	Mossad SI; Department of Psychology, The Hospital for Sick Children, Toronto, ON, Canada., Vandewouw MM; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.; Autism Research Center, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., de Villa K; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada., Pang EW; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.; Division of Neurology, Hospital for Sick Children, Toronto, ON, Canada., Taylor MJ; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.; Departments of Psychology and of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2022 Sep 20; Vol. 16, pp. 921347. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).
DOI:	10.3389/fnhum.2022.921347
Abstrakt:	Theory of Mind (ToM) is a core social cognitive skill that refers to the ability to attribute mental states to others. ToM involves understanding that others have beliefs, thoughts and desires that may be different from one's own and from reality. ToM is crucial to predict behaviour and navigate social interactions. This study employed the complementary methodological advantages of both functional MRI (fMRI) and magnetoencephalography (MEG) to examine the neural underpinnings of ToM in adults. Twenty healthy adults were first recruited to rate and describe 28 videos (15s long), each containing three moving shapes designed to depict either social interactions or random motion (control condition). The first sample of adults produced consistent narratives for 6 of those social videos and of those, 4 social videos and 4 control videos were chosen to include in the neuroimaging study. Another sample of twenty-five adults were then recruited to complete the neuroimaging in MEG and fMRI. In fMRI, we found increased activation in frontal-parietal regions in the social compared to the control condition corroborating previous fMRI findings. In MEG, we found recruitment of ToM networks in the social condition in theta, beta and gamma bands. The right supramarginal and angular gyri (right temporal parietal junction), right inferior parietal lobe and right temporal pole were recruited in the first 5s of the videos. Frontal regions such as the superior frontal gyrus were recruited in the second time window (5-10s). Brain regions such as the bilateral amygdalae were also recruited (5-10s), indicating that various social processes were integrated in understanding the social videos. Our study is one of the first to combine multi-modal neuroimaging to examine the neural networks underlying social cognitive processes, combining the strengths of the spatial resolution of fMRI and temporal resolution of MEG. Understanding this information from both modalities helped delineate the mechanism by which ToM processing unfolds over time in healthy adults. This allows us to determine a benchmark against which clinical populations can be compared. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mossad, Vandewouw, Villa, Pang and Taylor.)
Databáze:	MEDLINE
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