The intertwining between lead and ethanol in the model organism Caenorhabditis elegans .

Autor:	Albrecht PA; Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Instituto de Farmacología Experimental de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas (IFEC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Fernandez-Hubeid LE; Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Instituto de Farmacología Experimental de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas (IFEC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Deza-Ponzio R; Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Instituto de Farmacología Experimental de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas (IFEC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina., Virgolini MB; Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Instituto de Farmacología Experimental de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas (IFEC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Jazyk:	angličtina
Zdroj:	Frontiers in toxicology [Front Toxicol] 2022 Sep 20; Vol. 4, pp. 991787. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).
DOI:	10.3389/ftox.2022.991787
Abstrakt:	Caenorhabditis elegans (C. elegans) is a model organism widely used to evaluate the mechanistic aspects of toxicants with the potential to predict responses comparable to those of mammals. We report here the consequences of developmental lead (Pb) exposure on behavioral responses to ethanol (EtOH) in C. elegans . In addition, we present data on morphological alterations in the dopamine (DA) synapse and DA-dependent behaviors aimed to dissect the neurobiological mechanisms that underlie the relationship between these neurotoxicants. Finally, the escalation to superior animals that parallels the observed effects in both experimental models with references to EtOH metabolism and oxidative stress is also discussed. Overall, the literature revised here underpins the usefulness of C. elegans to evidence behavioral responses to a combination of neurotoxicants in mechanistic-orientated studies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Albrecht, Fernandez-Hubeid, Deza-Ponzio and Virgolini.)
Databáze:	MEDLINE
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