Changes in aortic diameter induced by weight loss: The HELENA trial- whole-body MR imaging in a dietary intervention trial.

Autor:	Stoll S; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Sowah SA; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Fink MA; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Nonnenmacher T; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Graf ME; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Johnson T; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Schlett CL; Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, Freiburg, Germany., von Stackelberg O; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Kirsten R; National Center for Tumor Diseases (NCT), Liquid Biobank, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bamberg F; Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, Freiburg, Germany., Keller J; Federal Office of Public Health, Bern, Switzerland., Ulrich CM; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, United States., Kaaks R; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Kauczor HU; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Rengier F; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany., Kühn T; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Nattenmüller J; Heidelberg University Hospital, Diagnostic and Interventional Radiology, Heidelberg, Germany.; Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2022 Sep 20; Vol. 13, pp. 976949. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).
DOI:	10.3389/fphys.2022.976949
Abstrakt:	Obesity-related metabolic disorders such as hypertension, hyperlipidemia and chronic inflammation have been associated with aortic dilatation and resulting in aortic aneurysms in many cases. Whether weight loss may reduce the risk of aortic dilatation is not clear. In this study, the diameter of the descending thoracic aorta, infrarenal abdominal aorta and aortic bifurcation of 144 overweight or obese non-smoking adults were measured by MR-imaging, at baseline, and 12 and 50 weeks after weight loss by calorie restriction. Changes in aortic diameter, anthropometric measures and body composition and metabolic markers were evaluated using linear mixed models. The association of the aortic diameters with the aforementioned clinical parameters was analyzed using Spearman`s correlation. Weight loss was associated with a reduction in the thoracic and abdominal aortic diameters 12 weeks after weight loss (predicted relative differences for Quartile 4: 2.5% ± 0.5 and -2.2% ± 0.8, p < 0.031; respectively). Furthermore, there was a nominal reduction in aortic diameters during the 50-weeks follow-up period. Aortic diameters were positively associated with weight, visceral adipose tissue, glucose, HbA1c and with both systolic and diastolic blood pressure. Weight loss induced by calorie restriction may reduce aortic diameters. Future studies are needed to investigate, whether the reduction of aortic diameters via calorie restriction may help to prevent aortic aneurysms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Stoll, Sowah, Fink, Nonnenmacher, Graf, Johnson, Schlett, von Stackelberg, Kirsten, Bamberg, Keller, Ulrich, Kaaks, Kauczor, Rengier, Kühn and Nattenmüller.)
Databáze:	MEDLINE
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