Couple stresses and discrete potentials in the vertex model of cellular monolayers.

Autor: Jensen OE; Department of Mathematics, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. oliver.jensen@manchester.ac.uk.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. oliver.jensen@manchester.ac.uk., Revell CK; Department of Mathematics, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Jazyk: angličtina
Zdroj: Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2023 Oct; Vol. 22 (5), pp. 1465-1486. Date of Electronic Publication: 2022 Oct 06.
DOI: 10.1007/s10237-022-01620-2
Abstrakt: The vertex model is widely used to simulate the mechanical properties of confluent epithelia and other multicellular tissues. This inherently discrete framework allows a Cauchy stress to be attributed to each cell, and its symmetric component has been widely reported, at least for planar monolayers. Here, we consider the stress attributed to the neighbourhood of each tricellular junction, evaluating in particular its leading-order antisymmetric component and the associated couple stresses, which characterise the degree to which individual cells experience (and resist) in-plane bending deformations. We develop discrete potential theory for localised monolayers having disordered internal structure and use this to derive the analogues of Airy and Mindlin stress functions. These scalar potentials typically have broad-banded spectra, highlighting the contributions of small-scale defects and boundary layers to global stress patterns. An affine approximation attributes couple stresses to pressure differences between cells sharing a trijunction, but simulations indicate an additional role for non-affine deformations.
(© 2022. The Author(s).)
Databáze: MEDLINE
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