A new cembranoid from the Red Sea soft coral Sarcophyton acutum .

Autor: Mohamed TA; Chemistry of Medicinal Plants Dept, Chemistry of Medicinal Plants, Dokki, Giza, Egypt., Abdelmawgoud SM; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egypt., Hamdy AA; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt., Elshamy AI; Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza, Egypt., Atia MAM; Molecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), ARC, Giza, Egypt., Kassem HA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Hegazy MF; Chemistry of Medicinal Plants Dept, Chemistry of Medicinal Plants, Dokki, Giza, Egypt., Selim NM; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Jan-Feb; Vol. 38 (3), pp. 512-522. Date of Electronic Publication: 2022 Oct 06.
DOI: 10.1080/14786419.2022.2130915
Abstrakt: The Red Sea soft coral Sarcophyton acutum ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A ( 1 ), along with six known metabolites have been isolated from S. acutum for the first time ( 2-7 ). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A ( 1 ) and gorgosterol ( 7 ) inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC 50 values of 35.5 and 44.0 μM, respectively.
Databáze: MEDLINE