Cinnamaldehyde for the Treatment of Microbial Infections: Evidence Obtained from Experimental Models.

Autor:	Silva E Silva Figueiredo CS; Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, Brazil.; Núcleo de Biomedicina, Universidade CEUMA, Imperatriz, MA, Brazil., de Oliveira PV; Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, Brazil., Dos Reis Ferreira L; Laboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís 65075-120, MA, Brazil., de Sousa TJD; Núcleo de Biomedicina, Universidade CEUMA, Imperatriz, MA, Brazil., de Santana do Nascimento M; Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, Brazil., Dos Santos JRA; Laboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Zagmignan A; Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, Brazil., de Holanda RA; Laboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís 65075-120, MA, Brazil., de Carvalho Galvão LC; Laboratório de Odontologia, Universidade CEUMA, São Luís 65075-120, MA, Brazil., da Silva LCN; Laboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, Brazil.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (31), pp. 3506-3526.
DOI:	10.2174/0929867329666221005105108
Abstrakt:	Cinnamaldehyde (CNM) is a cyclic terpene alcohol found as the major compound of essential oils from some plants of the genus Cinnamomum (Lauraceae). CNM has several reported pharmacological activities, including antimicrobial, antivirulence, antioxidant, and immunomodulatory effects. These properties make CNM an attractive lead molecule for the development of anti-infective agents. In this descriptive review, we discuss the application of CNM in experimental models of microbial infection using invertebrate and vertebrate organisms. CNM (pure or in formulations) has been successfully applied in the treatment of infections caused by a range of bacterial (such as Cronobacter sakazakii, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Streptococcus agalactiae, Vibrio cholerae ) and fungal (such as Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans ) pathogens. All these experimental evidence-based findings have promoted the use of cinnamaldehyde as the leading molecule for developing new anti- infective drugs. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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