Glutathione Peroxide and Glutathione to Disulfide Glutathione Ratio in Presbycusis: a Case-control Study.
| Autor: | Hasansulama W; Department of Otorhinolaryngology, Faculty of Medicine Universitas Padjadjaran. Hasan Sadikin General Hospital, Bandung, Indonesia.; Hasan Sadikin General Hospital, Bandung, Indonesia., Madiadipoera TS; Department of Basic Medical Science. Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Sunarjati; Department of Paediatrics. Faculty of Medicine, Universitas Padjadjaran/., Garna H; Hasan Sadikin General Hospital, Bandung, Indonesia. |
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| Jazyk: | angličtina |
| Zdroj: | Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2022 Jun; Vol. 76 (3), pp. 209-214. |
| DOI: | 10.5455/medarh.2022.76.209-214 |
| Abstrakt: | Background: Presbycusis is a gradual hearing loss caused by the ageing process. This is a chronic condition that affects the elderly population, and sensorineural progressive bilateral symmetry occurs with predominantly high-frequency hearing loss. The ability to discriminate speech decreases; hence, most of the affected patients have conversation problems, especially in noisy environments.This situation is a serious problem among elderly individuals. Social isolation, depression, and paranoia can be related to presbycusis. Objective: The aim of this study was to investigate GPx and the GSH:GSSG ratio as risk factors for presbycusis. Methods: A case-control study was conducted to determine the role of GPx activity with the GSH:GSSG ratio as a presbycusis risk factor in 60 subjects aged 55 to 75 years old during the period of August 2012 - April 2014. All of the subjects passed an ENT examination, pure tone audiometry, and tympanometry. The activity of GPx was measured with the Paglia and Valentine method, and the GSH:GSSG ratio was measured by the calorimetric method. Results: The activity of GPx and the GSH:GSSG ratio were significantly different between the groups (p<0.05), and the odds ratio for high GPx with a low GSH:GSSG ratio was 135 (CI 95%: 5.17-20,028.88). Conclusion: High GPx activity with a low GSH:GSSG ratio is a risk factor for presbycusis. Competing Interests: None declared. (© 2022 Wijana Hasansulama, Teti S Madiadipoera, Sunarjati, Herry Garna.) |
| Databáze: | MEDLINE |
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