Narrowing the difference in dose delivery for IOERT and IOBT for locally advanced and locally recurrent rectal cancer.

Autor:	Verrijssen AE; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, The Netherlands., Dries WJF; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Cnossen JS; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Theuws J; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Peulen HMU; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., van den Berg HA; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Rijkaart DC; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Voogt ELK; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Kolkman-Deurloo IK; Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Nuyttens J; Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Rutten HJT; GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, The Netherlands.; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Burger JWA; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Bimmel-Nagel CH; Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of contemporary brachytherapy [J Contemp Brachytherapy] 2022 Aug; Vol. 14 (4), pp. 370-378. Date of Electronic Publication: 2022 Jul 21.
DOI:	10.5114/jcb.2022.118305
Abstrakt:	Purpose: Intra-operative radiotherapy (IORT) has been used as a tool to provide a high-dose radiation boost to a limited volume of patients with fixed tumors with a likelihood of microscopically involved resection margins, in order to improve local control. Two main techniques to deliver IORT include high-dose-rate (HDR) brachytherapy, termed 'intra-operative brachytherapy' (IOBT), and electrons, termed 'intra-operative electron radiotherapy' (IOERT), both having very different dose distributions. A recent paper described an improved local recurrence-free survival favoring IOBT over IOERT for patients with locally advanced or recurrent rectal cancer and microscopically irradical resections. Although several factors may have contributed to this result, an important difference between the two techniques was the higher surface dose delivered by IOBT. This article described an adaptation of IOERT technique to achieve a comparable surface dose as dose delivered by IOBT. Material and Methods: Two steps were taken to increase the surface dose for IOERT: 1. Introducing a bolus to achieve a maximum dose on the surface, and 2. Re-normalizing to allow for the same prescribed dose at reference depth. Conclusions: We describe and propose an adaptation of IOERT technique to increase surface dose, decreasing the differences between these two techniques, with the aim of further improving local control. In addition, an alternative method of dose prescription is suggested, to consider improved comparison with other techniques in the future. Competing Interests: The authors report no conflict of interest. (Copyright © 2022 Termedia.)
Databáze:	MEDLINE
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