The association between QT interval changes and the treatment protocols of COVID-19 patients.

Autor:	Sertbas Y; Department of Internal Medicine, Health Sciences University, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye., Ozdil K; Department of Gastroenterology, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkiye., Terzi S; Department of Cardiology, Health Sciences University, Siyami Ersek Training and Research Hospital, Istanbul, Turkiye., Dagci S; Department of Gastroenterology, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkiye., Saylan B; Department of Chest Diseases, Health Sciences University, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Turkiye., Kizilay V; Department of Statistics, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkiye., Savas G; Department of Cardiology, Health Sciences University, Siyami Ersek Training and Research Hospital, Istanbul, Turkiye., Yaman AE; Department of Cardiology, Health Sciences University, Siyami Ersek Training and Research Hospital, Istanbul, Turkiye., Sertbas M; Department of Internal Medicine, Health Sciences University, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye., Yilmaz H; Departmant of Anesthesiology and Reanimation, Health Sciences University, Siyami Ersek Training and Research Hospital, Istanbul, Turkiye., Kocogullari CU; Departmant of Cardiovasculer Surgery, Health Sciences University, Siyami Ersek Training and Research Hospital, Istanbul, Turkiye.
Jazyk:	angličtina
Zdroj:	Northern clinics of Istanbul [North Clin Istanb] 2022 Jul 07; Vol. 9 (3), pp. 199-206. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).
DOI:	10.14744/nci.2022.86836
Abstrakt:	Objective: This study aimed to investigate the QT, QTc, and QTc dispersion changes that may occur with the use of hydroxychloroquine (HCQ), favipiravir, and moxifloxacin in combination or alone in COVID 19 patients. Methods: This study was retrospectively conducted on 193 inpatients diagnosed with COVID-19. We divided the patients into four separate groups due to their medications as, group-1: favipiravir, group-2: favipiravir + HCQ, group-3: favipiravir + moxifloxacin, and group-4: favipiravir + moxifloxacin + HCQ. We recorded their pre and post-treatment QT parameters of each group and evaluated the changes of these parameters with the SPSS statistical program. Results: The mean age of the patients was 63.1±17.7. In group 1 and 2, although there were slight changes in QT parameters, these results were not statistically significant. In group 3, significant increases in QT and QTc dispersion occurred (p=0.005 and p=0.018). In the 4 th group where the triple therapy was applied, there was a significant increase only in the QTc values (p=0.027). When we compared the changes of QT parameters for each group, a significant difference was found in ΔQTc dispersion, and post hoc analysis showed that it was due to changes in the third group (p=0.047). Conclusion: We thought that, if there is a COVID-19 infection with an additional bacterial infection, and if there is a need of using moxifloxacin alone or together with HCQ, additional risk factors that may cause QT interval prolongation should be reviewed and ECG monitoring of the patients should be performed during the treatment period. Competing Interests: No conflict of interest was declared by the authors. (© Copyright 2022 by Istanbul Provincial Directorate of Health.)
Databáze:	MEDLINE
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