Exploring the constituent mechanisms of hepatitis: a dynamical systems approach.
| Autor: | Dunster JL; Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AS, UK., Gibbins JM; Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AS, UK., Nelson MR; School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Mathematical medicine and biology : a journal of the IMA [Math Med Biol] 2023 Mar 13; Vol. 40 (1), pp. 24-48. |
| DOI: | 10.1093/imammb/dqac013 |
| Abstrakt: | Hepatitis is the term used to describe inflammation in the liver. It is associated with a high rate of mortality, but the underlying disease mechanisms are not completely understood and treatment options are limited. We present a mathematical model of hepatitis that captures the complex interactions between hepatocytes (liver cells), hepatic stellate cells (cells in the liver that produce hepatitis-associated fibrosis) and the immune components that mediate inflammation. The model is in the form of a system of ordinary differential equations. We use numerical techniques and bifurcation analysis to characterize and elucidate the physiological mechanisms that dominate liver injury and its outcome to a healthy or unhealthy, chronic state. This study reveals the complex interactions between the multiple cell types and mediators involved in this complex disease and highlights potential problems in targeting inflammation in the liver therapeutically. (© The Author(s) 2019. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications.) |
| Databáze: | MEDLINE |
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