Endolymphatic space is age-dependent.

Autor: Dieterich M; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Vertigo and Balance Disorders-IFB, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; Graduate School of Systemic Neuroscience (GSN), Ludwig-Maximilians-Universität, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Hergenroeder T; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany., Boegle R; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Vertigo and Balance Disorders-IFB, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; Graduate School of Systemic Neuroscience (GSN), Ludwig-Maximilians-Universität, Munich, Germany., Gerb J; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Vertigo and Balance Disorders-IFB, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany., Kierig E; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Vertigo and Balance Disorders-IFB, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany., Stöcklein S; Department of Radiology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany., Kirsch V; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany. vkirsch@med.lmu.de.; German Center for Vertigo and Balance Disorders-IFB, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany. vkirsch@med.lmu.de.; Graduate School of Systemic Neuroscience (GSN), Ludwig-Maximilians-Universität, Munich, Germany. vkirsch@med.lmu.de.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2023 Jan; Vol. 270 (1), pp. 71-81. Date of Electronic Publication: 2022 Oct 05.
DOI: 10.1007/s00415-022-11400-8
Abstrakt: Knowledge of the physiological endolymphatic space (ELS) is necessary to estimate endolymphatic hydrops (ELH) in patients with vestibulocochlear syndromes. Therefore, the current study investigated age-dependent changes in the ELS of participants with normal vestibulocochlear testing. Sixty-four ears of 32 participants with normal vestibulocochlear testing aged between 21 and 75 years (45.8 ± 17.2 years, 20 females, 30 right-handed, two left-handed) were examined by intravenous delayed gadolinium-enhanced magnetic resonance imaging of the inner ear (iMRI). Clinical diagnostics included neuro-otological assessment, video-oculography during caloric stimulation, and head-impulse test. iMRI data analysis provided semi-quantitative visual grading and automatic algorithmic quantitative segmentation of ELS volume (3D, mm 3 ) using a deep learning-based segmentation of the inner ear's total fluid space (TFS) and volumetric local thresholding, as described earlier. As a result, following a 4-point ordinal scale, a mild ELH (grade 1) was found in 21/64 (32.8%) ears uni- or bilaterally in either cochlear, vestibulum, or both. Age and ELS were found to be positively correlated for the inner ear (r(64) = 0.33, p < 0.01), and vestibulum (r(64) = 0.25, p < 0.05). For the cochlea, the values correlated positively without reaching significance (r(64) = 0.21). In conclusion, age-dependent increases of the ELS should be considered when evaluating potential ELH in single subjects and statistical group comparisons.
(© 2022. The Author(s).)
Databáze: MEDLINE
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