| Autor: |
D B; Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Thiruvanthapuram 695019, Kerala, India.; Academy of Scientific and Innovative Research (AcSIR, Ghaziabad 201002, India., C S A; Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Thiruvanthapuram 695019, Kerala, India.; Academy of Scientific and Innovative Research (AcSIR, Ghaziabad 201002, India., D SV; Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Thiruvanthapuram 695019, Kerala, India.; Academy of Scientific and Innovative Research (AcSIR, Ghaziabad 201002, India., T AK; Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Thiruvanthapuram 695019, Kerala, India.; Academy of Scientific and Innovative Research (AcSIR, Ghaziabad 201002, India., Somappa SB; Chemical Sciences & Technology Division, CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Thiruvanthapuram 695019, Kerala, India.; Academy of Scientific and Innovative Research (AcSIR, Ghaziabad 201002, India. |
| Abstrakt: |
An efficient, straightforward, and one-pot synthesis of biologically relevant spiro-dihydropyridine oxindoles was described via readily available isatin, malononitrile, allenoate, and amines. The metal/organocatalyst-free, Et 3 N-mediated reaction proceeds via cascade spiro-cyclization of in situ generated Knoevenagel/aza-Michael adducts. The reaction has great flexibility over electron-rich and electron-poor substituents affording desired products in good to excellent yields. We have also demonstrated the selected spiro-dihydropyridines for late-stage diversification into new spiro-dihydropyridine hybrids of pharmaceutical relevance. |
