Dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucagon-like peptide (GLP-1) secretion in arsenically safe pigmented red rice ( Oryza sativa L . ) and its product.

Autor: Samyor D; Department of Food Engineering and Technology, Tezpur University, Napaam, Sonitpur, Assam 784028 India.; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK., Calderwood D; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK., Carey M; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK., Das AB; Department of Food Engineering and Technology, Tezpur University, Napaam, Sonitpur, Assam 784028 India., Green BD; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK., Deka SC; Department of Food Engineering and Technology, Tezpur University, Napaam, Sonitpur, Assam 784028 India.
Jazyk: angličtina
Zdroj: Journal of food science and technology [J Food Sci Technol] 2022 Oct; Vol. 59 (10), pp. 4016-4024. Date of Electronic Publication: 2022 Apr 11.
DOI: 10.1007/s13197-022-05444-x
Abstrakt: Inhibition of DPP-4 and stimulation of GLP-1 secretion are therapeutic strategies for controlling glycaemia in type 2 diabetes. The present study assessed the DPP-4 inhibitory activity and GLP-1 secretory action of pigmented and non-pigmented rice ( Oryza sativa L . ), along with an extruded food product. Cereal-based extruded food products, with or without passion fruit powder, were prepared from red rice using a twin extruder. Optimal extrusion conditions were determined using a CCD of response surface methodology resulting in optimal conditions to be 97.5 °C, a screw speed of 250 rpm, feed moisture of 25.2% and addition of 11.25% passion fruit powder. Samples were sequentially extracted in n -hexane, ethanol (50%) and water. Ethanol/water (50:50) extracts of rice bran significantly inhibited DPP-4 activity by 70.48 ± 1.06%, comparing favourably with RR (42.55 ± 0.84%), PRR (35.91 ± 1.27%) and PA (29.14 ± 1.23%). DPP-4 inhibitory activity was retained in both extruded products albeit at reduced levels. GLP-1 secretion was stimulated mostly by extruded products extracted with n -hexane or ethanol which upregulated basal secretion by 6.1-fold and 4.2-fold, respectively. ICP-MS results showed that extruded food items have a lower arsenic content. In conclusion, there are potential opportunities for the nutraceuticals and functional food products using pigmented red rice.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13197-022-05444-x.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Association of Food Scientists & Technologists (India) 2022.)
Databáze: MEDLINE
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