Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw.

Autor: Hadad H; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil. henriquehadad@gmail.com., Kawamata de Jesus L; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil., Piquera Santos AF; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil., Rinaldi Matheus H; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil., de Souza Rodrigues LG; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil., Paolo Poli P; Department of Biomedical, Surgical and Dental Sciences, Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Marcantonio Junior E; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil., Pozzi Semeghini Guastaldi F; Skeletal Biology Research Center, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital (MGH), Harvard School of Dental Medicine, Boston, MA, USA., Maiorana C; Department of Biomedical, Surgical and Dental Sciences, Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Milanezi de Almeida J; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil., Okamoto R; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil., Ávila Souza F; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, Araçatuba, São Paulo, 16015-050, Brazil. francisley.avila@unesp.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Oct 03; Vol. 12 (1), pp. 16510. Date of Electronic Publication: 2022 Oct 03.
DOI: 10.1038/s41598-022-20128-4
Abstrakt: Surgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje