Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy.

Autor: Toh YL; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore., Tan CJ; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore., Yap NY; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore., Parajuli R; Department of Medicine, University of California, Irvine, USA., Lau AJ; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; College of Pharmacy, Dalhousie University, Halifax, Canada., Chan A; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore. a.chan@uci.edu.; Department of Pharmacy, National Cancer Centre Singapore, Singapore, Singapore. a.chan@uci.edu.; Department of Clinical Pharmacy Practice, University of California Irvine, Irvine, CA, USA. a.chan@uci.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Oct 03; Vol. 12 (1), pp. 16552. Date of Electronic Publication: 2022 Oct 03.
DOI: 10.1038/s41598-022-20420-3
Abstrakt: The purpose of this study is to elucidate how patient-reported cognitive symptoms manifest from variations in hormone levels or precursors such as dehydroepiandrosterone (DHEA) and its sulfated form [collectively termed as DHEA(S)] and to investigate their association in breast cancer survivors. Levels of estradiol and DHEA(S) were compared between early-stage breast cancer patients with and without cancer-related cognitive impairment (CRCI) during adjuvant chemotherapy. Data were analyzed from 242 patients (mean age ± SD = 50.8 ± 9.2 years) who had completed FACT-Cog v.3.0, blood draws and questionnaires. Regression model was used to fit the magnitude of change in each respective biomarker levels against overall cognitive impairment status while adjusting for clinically important covariates. There was reduction in mean plasma levels of estradiol and DHEAS during and towards the end of chemotherapy (p-values < 0.001). Compared to non-impaired patients, smaller magnitude of decline was observed in DHEA(S) levels in patients reporting CRCI, with significant association between decline in DHEAS levels and acute onset of CRCI at 6 weeks from baseline (adjusted β of 0.40, p-value of 0.02). In contrast, patients reporting CRCI showed greater magnitude of decline in estradiol compared to non-impaired patients, although this was not found to be statistically significant. There was an association between magnitude of change in biomarker levels with self-reported CRCI which suggests that the hormonal pathway related to DHEAS may be implicated in acute CRCI for breast cancer survivors. Our findings help to improve biological understanding of the pathway from which DHEAS may correlate with cognitive dysfunction and its impact on cancer survivors.
(© 2022. The Author(s).)
Databáze: MEDLINE
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