An Appraisal to Address Health Consequences of Vitamin D Deficiency With Food Fortification and Supplements: Time to Act!

Autor:	Reichrath J; Clinic for Dermatology, Allergology and Venerology, The Saarland University Hospital, Homburg, Germany; Joerg.reichrath@uks.eu.; Center for Clinical and Experimental Photodermatology (CECEP), The Saarland University Hospital, Homburg, Germany., März W; Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, Heidelberg, Germany.; Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., DE Gruijl FR; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., Vieth R; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Grant WB; Sunlight, Nutrition and Health Research Center, San Francisco, CA, U.S.A., Slominski AT; Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, U.S.A., Holick MF; Department of Endocrinology, Boston University Medical Campus, Boston, MA, U.S.A., Vogt T; Clinic for Dermatology, Allergology and Venerology, The Saarland University Hospital, Homburg, Germany.; Center for Clinical and Experimental Photodermatology (CECEP), The Saarland University Hospital, Homburg, Germany., Pilz S; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2022 Oct; Vol. 42 (10), pp. 5009-5015.
DOI:	10.21873/anticanres.16008
Abstrakt:	A symposium entitled "Vitamin D in Prevention and Therapy" was held on May 4-5, 2022, in Homburg, Germany to discuss important new advances in the field, including identification of new vitamin D signaling pathways, of new biologic effects of vitamin D-compounds (e.g., on the microbiome), and convincing proof of the relevance of vitamin D deficiency for the risk and outcome of many chronic diseases, including cancer, cardio-vascular, auto-immune, metabolic, and infectious diseases. Concerning the COVID-19-pandemic, an inverse association between 25(OH)D serum concentrations and SARS-CoV-2-infections, morbidity, and mortality was shown. In relation to cancer, several meta-analyses recently demonstrated an association of vitamin D-supplementation with significantly decreased mortality rates, which presumably would reduce health care costs. Considering the impressive body of evidence and the high safety of oral supplementation and food fortification with vitamin D, it was concluded that there is now an urgent need to act. In many countries worldwide, health care authorities need to increase efforts to address vitamin D deficiency, e.g., via food fortification and/or supplementation with vitamin D, and/or promoting moderate UV-exposure. It was estimated that in many countries, vitamin D intakes of the order of appr. 1,000 IE (25 μg)/day would be needed to bring and/or keep the vast majority of people over a serum 25(OH)D threshold of 20 ng/ml (50 nmol/l), which would be difficult to obtain alone from food fortification. New developments in personalized medicine may represent helpful tools to identify populations at risk for vitamin D deficiency and their responsiveness to vitamin D treatment. (Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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