Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study.

Autor:	Felt JM; Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA., Harrington KD; Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA., Ram N; Department of Communications, Stanford University, Stanford, California, USA.; Department of Psychology, Stanford University, Stanford, California, USA., O'Donnell KJ; Child Study Center, Yale University, New Haven, Connecticut, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, Connecticut, USA.; The Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Child and Brain Developmental Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada., Sliwinski MJ; Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA., Benson L; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA., Zhang Z; Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania, USA., Meaney MJ; The Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Child and Brain Developmental Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.; Singapore Institute of Clinical Sciences, Singapore., Putnam FW; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Noll JG; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA., Shenk CE; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Pediatrics, The Pennsylvania State University School of Medicine, University Park, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series B, Psychological sciences and social sciences [J Gerontol B Psychol Sci Soc Sci] 2023 Apr 01; Vol. 78 (4), pp. 585-595.
DOI:	10.1093/geronb/gbac158
Abstrakt:	Objectives: Deviations from normative trajectories of receptive language abilities following early life adversity (ELA) may indicate an elevated risk for advanced cognitive aging and related morbidities. Accelerated epigenetic aging at midlife may further identify those at greatest risk for advanced cognitive aging following ELA. We examined whether accelerations in epigenetic aging at midlife can identify those individuals who demonstrated the greatest change in receptive language abilities following ELA. Methods: Data were drawn from the Female Growth and Development Study (n = 86), a 30-year prospective cohort study of females exposed to substantiated child sexual abuse (CSA), a severe ELA, and a non-CSA comparison condition. The Peabody Picture Vocabulary Test-Revised (PPVT-R) measured receptive language abilities on 6 occasions from childhood to mid-life. Interindividual differences in PPVT-R trajectories were examined in relation to CSA exposure and across 5 independent measures of epigenetic age acceleration derived from first (Horvath DNAmAge, Hannum DNAmAge) and second (GrimAge, PhenoAge, Dunedin Pace of Aging) generation epigenetic clocks. Results: Quadratic growth models revealed that PPVT-R scores were significantly lower at age 25 for females exposed to CSA. Specifically, CSA exposed females had lower intercepts when GrimAge was accelerated and a smaller quadratic trend when PhenoAge was accelerated. Discussion: ELA is associated with significant differences in development of receptive language abilities with the most pronounced differences observed for females with accelerated epigenetic ages at mid-life. These findings suggest that epigenetic age acceleration could serve as an indicator of differences in cognitive aging and portend to later adulthood cognitive functioning. (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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