Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study.

Autor: Nielsen TC; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia., Nassar N; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia., Shand AW; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia.; Department of Maternal Fetal Medicine, Royal Hospital for Women, Sydney, Australia., Jones HF; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia.; Starship Children's Hospital, University of Auckland, Auckland, New Zealand., Han VX; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Patel S; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia., Guastella AJ; Brain and Mind Centre, University of Sydney, Sydney, Australia., Dale RC; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia., Lain SJ; Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia.
Jazyk: angličtina
Zdroj: Autism research : official journal of the International Society for Autism Research [Autism Res] 2022 Dec; Vol. 15 (12), pp. 2371-2380. Date of Electronic Publication: 2022 Oct 03.
DOI: 10.1002/aur.2824
Abstrakt: The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associated with increased risk of ASD in previous studies, but potential synergistic effects remain underexplored. We conducted a population-based cohort study of singleton children born at term gestation (37-41 weeks) in New South Wales, Australia from January 2002 to December 2008. Maternal autoimmune diagnoses and childhood infections before age 2 years were identified from linked maternal and child hospital admissions, and ASD diagnoses by age 9 years were identified from linked disability services data. Multivariable logistic regression assessed the association between each exposure and ASD and additive interaction between exposures, controlling for potential confounders. A total of 18,451 children exposed to maternal autoimmune disease were propensity score matched (1:2) to 36,902 unexposed children. Any maternal autoimmune disease (adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07-1.47) and any childhood infection before age 2 years (aOR 1.38, 95% CI 1.15-1.67) were each associated with ASD. However, there was no evidence of additive interaction between the two exposures (relative excess risk due to interaction [RERI] 0.128, 95% CI -0.418-0.675) resulting in increased odds of ASD in offspring. Future studies could examine potential interactions between other sources of maternal immune activation and childhood infection and impact on ASD and other neurodevelopmental disorders.
(© 2022 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.)
Databáze: MEDLINE
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